Clinical Research Directory

Open-label Study to Evaluate Long-term Safety and Efficacy of SPN-812 (Viloxazine Extended-release Capsule)

Open label extension, long-term multicenter study of safety and efficacy of SPN-812 in pediatric ADHD patients

Fronto-Parietal Transcranial Alternating Current Stimulation for ADHD in Children and Adolescents

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition in children and adolescents and is often associated with difficulties in attention, inhibitory control, working memory, and other executive functions. The fronto-parietal brain network is thought to play an important role in these cognitive functions. Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation technique that may influence brain activity. This study aims to evaluate whether 5-Hz tACS targeting the right frontal and parietal regions can improve executive functioning in children and adolescents aged 6 to 18 years with ADHD. The study also aims to explore whether any effects of tACS are related to changes in brain activity measured by electroencephalography (EEG). Participants will receive both active tACS and sham stimulation in a randomized, double-blind, crossover design. Clinical symptoms, executive function performance, and EEG measures will be assessed before and after each stimulation session. The main hypothesis is that active fronto-parietal tACS will produce greater improvement in executive functioning than sham stimulation, and that these effects may be associated with changes in EEG-measured brain activity.

The Effects of Cannabigerol on Attention-Deficit/Hyperactivity Disorder

The goal of this clinical trial is to evaluate the effects of Cannabigerol (CBG) on indicators of Attention-Deficit/Hyperactivity Disorder (ADHD) in a sample of participants indicating/reporting symptoms associated with ADHD. The main question it aims to answer is: Does CBG reduce ADHD-related indicators relative to placebo? Participants will administer an acute dose of placebo or 80mg CBG and complete outcome measures at 45 minutes and 75 minutes. Daily surveys to monitor safety will be administered for one week following administration.

Evaluation of SPN-812 (Viloxazine Extended-release Capsule) in Preschool-age Children With ADHD

This study will evaluate the efficacy and safety of SPN-812 (viloxazine extended release) in children 4 to 5 years of age with ADHD.

Fibromyalgia Disease Burden in Mothers of Children With Attention-Deficit/Hyperactivity Disorder

In this study, the investigators aimed to evaluate the impact of having a child diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) on parental disease burden in mothers diagnosed with Fibromyalgia Syndrome (FMS). The study will include 50 mothers with FMS who have a child diagnosed with ADHD and 50 mothers with FMS who have children without any psychiatric disorders. Among mothers of children followed with a diagnosis of ADHD at the Child and Adolescent Psychiatry Outpatient Clinic of Edirne Sultan 1st Murat State Hospital, the presence of widespread body pain will be assessed. Mothers reporting widespread body pain will be referred to the Pain Management Outpatient Clinic of the same hospital for further evaluation for FMS. Mothers diagnosed with FMS will be included in the study group. The comparison group will consist of mothers with FMS who have children without any psychiatric disorders. These participants will be selected from patients diagnosed with FMS who present to the Pain Management Outpatient Clinic of Edirne Sultan 1st Murat State Hospital.

A Pilot Study on Efficacy of Digital Therapeutic NDTx-02 for Executive Function in Children and Adolescents With ADHD or ASD

The purpose of this study is to explore the preliminary safety and effectiveness of the digital therapeutic device 'NDTx-02' in supporting improvements of executive function in children and adolescents diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) or Autism Spectrum Disorder (ASD).