Clinical Research Directory

Targeting Social Function in Anxiety and Eating Disorders

Social processing and cognition are often altered in patients with eating disorders. The goal of this clinical trial is to assess two different social therapeutic interventions -- one educational, one interactive -- for their effectiveness in improving clinical outcomes in patients with eating disorders. Patients in both interventions will receive education about social function in eating disorders, but those in the interactive treatment group will complete an additional collaborative art task. Participants will: * attend a baseline study visit to complete clinical interviews, cognitive testing, and behavioral tasks * complete a pre-intervention assessment with questionnaires * attend eight sessions of their assigned treatment group over the course of 12 weeks * complete three virtual follow-up assessments 4, 8, and 12 months from their baseline * attend a final study visit to repeat some clinical interviews, cognitive testing, and behavioral tasks Researchers will compare changes in eating disorder, mood, and anxiety symptoms as well as test results from baseline and final study visits for each group to see if * patients can be treated effectively with education alone or if an interactive group component produces additional benefits * cognitive and behavioral task performance are associated with recovery or illness state.

The Role of a Brief Educational Video Series for Parent of Adolescents With Anorexia Nervosa

The goal of this clinical trial is to learn if a brief parent educational video series is feasible, acceptable, and effective for improving parent and patient outcomes for adolescents with Anorexia Nervosa. The main questions it aims to answer are: Do parents want to watch these educational videos and find them helpful/useful ? Do parents who watch the videos report improvement in their knowledge about restrictive eating disorders and self-efficacy in helping their child recover, as well as reductions in stress and burden associated with parenting a child with anorexia? Do adolescents (ages 10-16) report improvements in their eating disorder symptoms when their parents watch these videos? Investigators will compare treatment as usual (traditional family and individual therapy with regular medical and nutrition visits) to treatment as usual plus the parent educational videos to see if the videos improve parental and patient outcomes beyond treatment as usual. Parent and adolescent participants will complete baseline measures including: Parent measures: eating disorder knowledge, self-efficacy, stress and burnout Patient (adolescent) measures: eating disorder symptoms, depression symptoms, anxiety symptoms Parents will complete these measures immediately after first meeting with their child's medical doctor to confirm a diagnosis of a restrictive eating disorder and then again 3 months later. The investigators will also assess the video feasibility and acceptability by asking parents to report their satisfaction with the videos and to assess how many approached families enroll in the study.

Feasibility and Acceptability of Metacognitive Training for Eating Disorders in Adolescents With Anorexia Nervosa

This study aims to assess the feasibility and acceptability of Metacognitive Training for Eating Disorders (MCT-ED) in adolescents with anorexia nervosa and atypical anorexia nervosa.

Individualized Study of Refeeding to Optimize iNpatient Gains

The primary purpose of the trial is to compare the efficacy and safety of Individualized Caloric Refeeding (ICR) to the new standard of care, Higher Calorie Refeeding (HCR), in hospitalized patients with atypical anorexia nervosa (AAN), and clinical remission over one year of follow-up.

Ketone Supplementation in Eating Disorders

This study will investigate the effects of ketone supplementation on eating behavior including drive to binge eat or restrict, mood and anxiety in individuals with anorexia or bulimia nervosa. In addition, the investigators will contrast the effects of active ketone supplementation versus placebo on electroencephalogram (EEG) measurement. All subjects enrolled in the study will undergo EEG on two consecutive days at the beginning of the study, after active ketone supplementation or placebo drink, matched in taste to the ketone drink. Days will be randomized. Thereafter, all subjects will take the ketone supplementation drink for two weeks, twice daily.

tDCS and Cognitive Training for Restrictive Eating Disorders

This study looks at adults with restrictive eating disorders who are currently receiving outpatient treatment for their eating disorder to examine whether a new brain stimulation technique called non-invasive transcranial direct current stimulation (tDCS) can enhance brain training. Participation involves interviews, assessments, 10 sessions of brain stimulation (active or sham), and computerized brain training over a 3-4 week period, with one post-intervention visit, and one 1-month follow-up visit.

Ketamine Effects on Learning In Eating Disorders

This is a single site, single dose clinical trial of intravenous (IV) ketamine for medically hospitalized adolescents and young adults with anorexia nervosa or atypical anorexia nervosa. Eating disorder symptoms will be measured pre- and post-ketamine infusion. Investigators hypothesize that ketamine will increase cognitive flexibility, making medical hospitalizations less distressing by improving the ability to learn new, positive associations with food.