Clinical Research Directory

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1 clinical study listed.

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C9orf72 Amyotrophic Lateral Sclerosis (ALS)

Tundra lists 1 C9orf72 Amyotrophic Lateral Sclerosis (ALS) clinical trial. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.

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ACTIVE NOT RECRUITING

NCT04220021

Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD

The primary objective is to assess the safety and tolerability of Metformin in subjects with C9orf72 amyotrophic lateral sclerosis administered for 24 weeks. The overall objective is to determine if Metformin is safe in C9orf72 ALS patients and is a potentially viable therapeutic treatment for C9-ALS that reduces repeat-associated non-canonical start codon - in DNA (non-ATG) (RAN) proteins that are produced by the C9orf72 repeat expansion mutation.

Gender: All

Ages: 18 Years - 80 Years

Updated: 2025-12-02

1 state

C9orf72 Amyotrophic Lateral Sclerosis (ALS)

Frontotemporal Dementia