Clinical Research Directory

Mental And Speech Developmental Delay Autism Spectrum-Type Behavioral Disorder

FAMILY SYSTEM CITADEL 2060.METHODOLOGY "VOICE OF SLEEP MAMABEE 2026-2085 Systemic work with brain neurons through training modules at the border of sleep in clinical, psychological and strategic logic. Training modules of fairy tale in brain simulation, restoration of the nervous system core in real time. Strategic model of the generational horizon: 2nd, 3rd, and 4th generations. AUTONOMOUSLY. OPERATES REMOTELY: FORMAT: Training basic modules are listened to before sleep. Transit modules are listened to during the day. PSYCHOLOGICAL COMFORT AND PROTECTION: Complete exclusion of direct contact between the child and doctors to avoid stress. The child remains in an absolutely safe, familiar home environment. Listening to the modules is conducted according to the protocol of the approved family physician or psychologist under strict control: "Mother ⇄ Child". SEQUENCE OF PROGRAM MODULES: FOUNDATION: Four sequential modules for the formation of new neural connections in the brain. TRANSIT MODULES: Three verb-based poems for locking in sequential results and retaining neurons. BASIC MODULE (foundation): Systemic cultivation of the child's personality vertical from birth. One national-historical poem lays an unbreakable inner core for life, changing a person's fate and protecting the legacy of the whole family for decades to come. Three levels of monolithic strength: neurobiological, psychogenetic, and geopolitical.: PROGRAM COMPLETION: Fifth module, "The Road Home." The child independently walks to the grocery store and back as consolidation of an autonomous everyday living skill. CLINICAL OUTCOME (February-June 2026, 0-3-6 cycle) Speech development: 3rd month of the 0-3-6-9 work cycle April 21, 2026. Progress in communication: the first clear, quick, and conscious answer to the mother's question. Transition from echolalia to conscious speech. Fine motor skills: A sharp developmental leap was recorded. The child began assembling puzzles significantly faster and more accurately. Physical activity: Growth in training performance indicators was recorded. The child began running faster and regularly updates his personal sports records. Independence: Began performing complex motor exercises without visual prompts, guided only by the coach's verbal instructions. First steps toward an independent trip to the grocery store: gets dressed, takes the bag, and locks the door with the key. Independence: The child demonstrates the first successful steps toward going to the store independently on foot. He gets fully dressed by himself, takes the bag, and closes the front door behind him with the key. Psycho-emotional state of the child. Sleep quality: Since February, from the start of listening to the fairy tales, deep, healthy, and stable nighttime sleep without awakenings has been noted. Dynamics of the mother's psycho-emotional state May 1, 2026: The mother recorded a state of complete inner calm. Restoration of the core nervous system. Return of life resources over 19 years. Audio modules: Individual podcasts were written for the mother. She regularly listens to them at night. CORE OF THE SYSTEM NEUROBIOLOGICAL CONNECTION BETWEEN MOTHER AND CHILD: The brain of a child on the autism spectrum instantly reads the mother's stress micro-signals (cortisol field). The system works directly with the core of the mother's nervous system: it restores sleep, returns the will to live, and enables positive resolution of set tasks. Healthy parents = healthy child, a fundamental condition for neuroplasticity, which automatically relaxes the child's tense nervous system. Strategic level: Turning the diagnosis into a profession, survival experience, and dynastic continuity of all families with a 2026-2085 horizon. The national-historical foundation and the value of family cultivate the child's personality vertical, making him resilient to any external crises, emigration, social upheavals, and attempts to erase his personality. By protecting the child's brain through training modules, you protect the family's assets and culture for decades ahead. CHILDREN IN THE SYSTEM (METHODOLOGY TARGET GROUPS): Children with ASD, ADHD, Down syndrome, motor alalia, speech development delay, trauma-related adaptation difficulties, mutism, sleep disorders, rehabilitation needs, and high-perception children in bilingual or elite environments. NATALIA POLUEKTOVA Independent Humanitarian Strategist. Children and Families in Healthcare. Preservation of Generational Heritage.

A Treatment for a Form of Age-Related Central Auditory Processing Disorder Consisting of Clemastine Fumarate Plus Engineered Sound

The goal of this clinical trial is to determine the efficacy of Clemastine Fumarate in the presence of engineered sound to treat age-related central auditory processing disorder (CAPD). This disorder impacts 800M patients worldwide, including \~1/3 people over 40 years of age and \~1/2 people over 65, resulting in an inability to hear in noisy environments. The primary hypothesis this study aims to test is: engineered sound, driving localized neural circuit activity, will enable Clemastine Fumarate to mature Oligodendrocyte cells and thus remyelinate these activated neural circuits. This Localized Oligodendrocyte Optimization Therapy (LOOT) was highly effective in preclinical animal studies so this clinical trial aims to answer if this therapy will translate to humans. The study is an adaptive design intended to compare the efficacy of the drug in the presence or absence of the engineered sound for improving hearing in noise ability. Trial participants will be tested for hearing thresholds and ability to isolate a sound signal from background noise. If they meet the inclusion criteria, they will be enrolled into one of the four arms of the study and undergo the proposed one-month treatment (drug and sound or respective placebos). After the treatment period, trial participants will be tested again for hearing thresholds and their ability to isolate s sound source of interest from background noise. The hypothesis to be tested in this clinical trial is that the one-month treatment will significantly improve the participant's ability to isolate a sound source of interest from background noise. The design has four arms, drug+sound, placebo+sound, drug+white noise, and placebo+white noise. Based on our preclinical data, control arms are all expected to show identical results, thus our adaptive design includes interim analyses to allow for dropping of two of the three placebo arms should the preclinical results be replicated as anticipated. We will also monitor each participant's general health during the duration of the clinical trial, which will be done by performing a number of blood tests, an EKG and a general physical before and after the one-month treatment period. We expect no significant changes since participants will take the drug for the one-month period at dosages already demonstrated safe in several Phase II studies of multiple sclerosis. Similarly, the engineered sound will be listened to for one hour per day during this month at sound intensities well below threshold that might cause noise-induced hearing damage.

Sleep and Central Auditory Processing Disorder in Autism Spectrum Disorder

The proposed study aims to understand poor sleep as a possible cause to CAPD in children and adolescents with ASD (ASD+) compared to ASD youth without CAPD (ASD-), using both caregiver-report and objective clinician administered measures. Additionally, the study will aim to understand the complex relationship between CAPD, sleep, and other associated phenotypic features of ASD such as executive and psychiatric functioning.