Clinical Research Directory

Effect of Botulinum Toxin on Selective Motor Control and Pain in Diplegic Cerebral Palsy

The aim of this study is to investigate the effects of Botulinum Neurotoxin-A (BoNT-A) injection applied to spastic muscles on pain sensation and Selective Motor Control (SMC) in cases diagnosed with diplegic spastic Cerebral Palsy.

Oculomotor Training in Spastic Diplegia: Effects on Postural Stability and Motor Proficiency

This randomized clinical trial investigates the effect of oculomotor training on postural stability and motor proficiency in children with spastic diplegia. Participants will undergo structured oculomotor exercises designed to enhance visual-motor integration and balance control. Outcomes will be assessed using standardized measures of postural stability and motor proficiency before and after intervention. The study aims to determine whether targeted oculomotor training can improve functional motor performance and balance in this pediatric population. By evaluating the effect of structured oculomotor training on postural stability and motor proficiency in children with spastic diplegia, the study seeks to establish whether visual-motor interventions can serve as effective adjuncts to conventional therapy. The rationale is grounded in neuroplasticity: repeated oculomotor exercises may strengthen neural pathways linking visual input to motor output, thereby improving balance and functional performance.

Intranasal AAV9-PHP.eB Gene Therapy in Cerebral Palsy (CP) & Hypoxic Ischemic Encephalopathy (HIE)

This international study, organized by Healing Hope International, is an observational registry designed to collect real-world data on participants living with chronic hypoxic ischemic encephalopathy (HIE) who receive an emerging intranasal gene therapy based on the AAV9-PHP.eB viral vector. The investigational therapy delivers a panel of 15 restorative genes that support brain repair, reduce inflammation, promote myelination, and improve neural communication. It is administered intranasally in one or three sessions by participating international clinical teams. Because the therapy is already being offered abroad, this registry does not assign treatment but instead follows participants who have received it as part of their existing medical care. The GEN HOPE Study aims to understand how this gene therapy affects movement, cognition, spasticity, and seizure frequency over time. Families and clinicians will share outcomes such as changes in gross motor function (GMFM-66/88), cognitive assessments (Bayley or WISC tests), and quality-of-life measures. Information on safety, laboratory results, MRI findings, and caregiver-reported experiences will also be collected. By combining data from multiple countries, the registry seeks to evaluate whether this novel gene based approach can meaningfully improve daily function and comfort for participants with chronic HIE. Results will guide future clinical trial development and help define safe and effective standards of care for regenerative neurologic therapies.

Effect of Blood Flow Restriction With Aerobic Training on Chest Muscles in Diaplegic Cerebral Palsy

To evaluate the effect of blood flow restriction combined with aerobic training on chest muscle strength in individual with diaplegic cerebral palsy

Effect of Eye Movement Exercise on Gait Spatial and Temporal Parameters in Cerebral Palsy Spastic Diplegic Children

The purpose of this study is to determine if there is an effect of eye movement training exercises on gait kinetic variables in cerebral palsy spastic diplegic children.