Clinical Research Directory

Efficacy and Safety Study of Halneuron in the Treatment of Chemotherapy-Induced Neuropathic Pain

A randomized study to determine safety and efficacy of a series of subcutaneous (SC) injections of HAL in patients with CINP, compared to matching placebo injections. After that, subjects may have the option to enter an Open Label extension phase, where available, in which all subjects will receive Halneuron.

The Effect of Foot Massage With a Massage Roller on Chemotherapy-Related Neuropathic Pain

Chemotherapy-related neuropathic pain is experienced by 30-40% of cancer patients. This pain significantly reduces the quality of life and overall well-being of patients battling cancer. Studies widely acknowledge that standardizing neuropathic pain assessment leads to improved patient outcomes. Our project, which we believe will add a different dimension to nursing care for cancer patients, aims to reduce chemotherapy-related neuropathic pain experienced by cancer patients through foot massage. The study population will consist of male and female cancer patients with chemotherapy-related neuropathic pain (VAS ≥ 4/10), over 18 years of age, who are actively undergoing treatment at the Medical Oncology Clinics of Atatürk University Research Hospital between February 1, 2026 and June 30, 2026, and who are not scheduled for surgical procedures during the research period. Accordingly, the minimum number of participants required for the study has been determined as 52. To reduce the risk of possible losses, withdrawals, or missing data during the research process, it is planned to include more participants than the calculated sample size. Within the scope of the research, the Neuropathic Pain Scale (S-LANSS) will be used to determine the presence of neuropathic pain in patients, and the VAS will be used to determine the severity of the pain. After the pre-test is completed, the control group will continue with routine treatment and care in the clinic. The intervention group will receive routine treatment and care, as well as foot massage using a foot massage roller for a total of 30 minutes twice a day. This intervention in the intervention group is planned to continue for 3 weeks. During this period, no other treatment will be applied to patients for neuropathic pain. The fact that only 3 small-scale studies, including one case report, were found in the literature review on this subject, the multidisciplinary collaboration in planning this study, and the expectation that it will offer practical solutions for chemotherapy-related neuropathic pain highlight the originality of the study. It is expected that the results obtained will provide evidence-based contributions to nursing care, support holistic approaches to improving patient comfort, and develop a viable intervention model for healthcare professionals.

Helping Cancer Patients Manage Neuropathy Symptoms From Chemotherapy With a Low-Intensity, Low-Risk Cranial PEMF Device

The goal of this clinical trial is to examine a low-intensity, low-risk cranial PEMF device and its effectiveness with helping cancer patients manage neuropathy symptoms from chemotherapy. Eligible patients are individuals who have been diagnosed with chemotherapy-induced peripheral neuropathy or are experiencing pain due to chemotherapy and are eighteen to sixty. The main questions the study aims to answer are: To examine whether the application of low intensity, low frequency PEMF (by the System for Heterogeneous Integrated magnetic Field Transmission (SHIFT)) results in a significant decrease in neuropathic pain intensity. To examine if SHIFT results in a decrease of pain related interference and associated symptoms of CIPN. Researchers will compare an active, treatment arm to a placebo, SHAM arm. Participants will be required to use the device once daily, fill out daily, weekly, and monthly surveys. They will have to do one blood draw at the beginning of the study and one at the end of the study.

The Effect of a Gamified Neuropathy Management Application on Cancer Behavior in Cancer Patients Undergoing Chemotherapy

This study will be conducted to determine the effect of a gamified neuropathy management application on cancer behavior in cancer patients undergoing chemotherapy.