Clinical Research Directory

Transperineal Versus Transrectal Cognitive Fusion Prostate Biopsy

This prospective randomized controlled trial aims to compare transperineal and transrectal cognitive fusion prostate biopsy techniques in patients with suspicious prostate lesions detected by multiparametric magnetic resonance imaging (mpMRI). Patients aged 50-75 years with PI-RADS 3-5 lesions on mpMRI and an indication for prostate biopsy will be randomly assigned in a 1:1 ratio to undergo either transperineal cognitive fusion prostate biopsy or transrectal cognitive fusion prostate biopsy. The primary objective of this study is to evaluate whether transperineal cognitive fusion biopsy is non-inferior to transrectal cognitive fusion biopsy in detecting clinically significant prostate cancer (csPCa). Secondary objectives include comparison of overall prostate cancer detection rates, detection of Gleason Grade Group ≥2 prostate cancer, biopsy-related infectious complications, other procedure-related complications, pain scores, and procedure duration. A total of 280 participants will be enrolled. Pathological evaluation will be performed after biopsy, and clinical outcomes and complications will be assessed during follow-up.

Acceptance and Commitment Therapy on Psychological Flexibility, Values, and Well-Being: A Single-Case Experimental Study

The goal of this clinical trial is to evaluate the effects of a brief Acceptance and Commitment Therapy (ACT)-based group intervention on psychological flexibility, values-based functioning, and psychological well-being in university students aged 18 to 28 years presenting elevated levels of emotional distress and psychological risk indicators. The main questions it aims to answer are: Does a brief ACT-based intervention reduce experiential avoidance and cognitive fusion in university students? Does the intervention improve present-moment awareness, values-based functioning, life satisfaction, and psychological flourishing? Participants will: Complete repeated self-report assessments across 13 measurement points distributed throughout baseline, intervention, and follow-up phases. Participate in five weekly ACT-based group intervention sessions delivered by trained clinical psychologists. Engage in experiential ACT exercises focused on acceptance, mindfulness, cognitive defusion, values clarification, and committed action. Complete between-session activities and behavioral practices related to the ACT processes addressed during the intervention. Participate in follow-up assessments to evaluate maintenance of treatment effects over time.