Clinical Research Directory

Investigation of the Effect of Nursing-Led Rehabilitation Interventions on Patient Care Outcomes in Patients Undergoing Coronary Artery Bypass Graft Surgery

Cardiovascular diseases are one of the leading causes of death globally. In addition to medical treatment and lifestyle changes, open heart surgery treatment also has an important place in the treatment of cardiovascular diseases. CABG surgery is the most common treatment aimed at improving patients' survival and quality of life. The rehabilitative interventions applied include all of the practices that accelerate the management of the disease in individuals with coronary heart disease and the individual's return to the living conditions before the disease. In our country, the cardiac rehabilitation process is carried out in a few centers , and a separate cardiac surgery rehabilitation program is not carried out. The study to be carried out will be the first in this field in our country. With the unit to be established; Rehabilitative interventions applied after coronary artery bypass graft surgery enable individuals to evaluate risk factors, help with any changes in their lifestyle, gain more information about the disease, increase their capacity by increasing cardiac/respiratory function, reduce the physical and psychological effects of the disease and enable them to act independently in their daily activities, Thus, it is aimed to increase the quality of life of individuals. To increase individual and social recovery, to manage and monitor the process by ensuring that families are involved in the process; It is aimed to ensure that it is evaluated and managed by the team (kvc specialist, cardiologist, clinical exercise physiologist, physiotherapist, nurse, dietitian, psychologist, coach) in order to ensure a multidisciplinary approach.

BRIDGE Trial: Embedding Consumer-grade mHealth Technologies Into Cardiac Rehabilitation

The purpose of the BRIDGE study is to learn whether supplementing traditional center-based cardiac rehabilitation (CBCR) with a mobile health technology intervention can help patients monitor their health, stay engaged in healthy lifestyle behaviors, better manage cardiovascular risk factors, and improve overall health outcomes. Cardiac rehabilitation is an evidence-based outpatient program designed to help people recover from heart-related conditions through supervised exercise, education, counseling, and support for healthy lifestyle changes. Although cardiac rehabilitation is highly recommended and beneficial, many patients do not receive the full benefits of the program. Some patients attend fewer sessions than recommended, and many find it difficult to maintain healthy habits outside of the clinic, such as regular physical activity, heart-healthy eating, taking medications as prescribed, monitoring blood pressure, and managing weight. This study will test whether combining CBCR with mobile health tools may improve participation and support healthy behaviors at home. Mobile health tools include mobile phone applications, connected devices such as a weight scale, blood pressure monitor, and activity tracker, as well as personalized text messages designed to encourage and support healthy self-care. This study will help determine whether these mobile health tools can make cardiac rehabilitation more effective and help patients maintain healthy behaviors beyond the clinic setting.

A Single Centre Study Comparing Continuous Interstitial Fluid Lactate Detection to Standard Measurements of Lactate in Patients Undergoing Elective Coronary Artery Bypass Graft Surgery and/or Valve Replacement.

The main goal of this study is to see if a wearable device can reliably track changes in lactate levels in the body. We\'ll compare the device\'s readings to standard blood tests to ensure accuracy. If successful, this device could reduce the need for frequent blood tests during surgery recovery, making patients more comfortable. It might also be useful in emergency rooms for quick diagnoses, especially for patients with chest pain. This study will take place at Barts Hospital with patients having planned coronary artery bypass graft (CABG) and/or replacement valve surgery. Participants will wear the sensors on their upper arm, during which the sensors will continuously measure lactate levels. Participants will also have hourly blood samples taken. In the future, the data from this new device will be used to train computer algorithms to provide quick responses that help manage a patient\'s condition, improving future medical care and technology.

Mechanical Power and Pulmonary Complications in CABG Surgery

This prospective observational study evaluates the association between intraoperative mechanical power (MP) - a composite measure of the total energy delivered to the lungs during mechanical ventilation - and postoperative pulmonary complications (PPCs) and prolonged mechanical ventilation in adult patients undergoing elective coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB). Intraoperative ventilatory parameters including tidal volume, respiratory rate, airway pressures, and PEEP will be recorded and used to calculate MP and driving pressure (DP). No additional interventions will be applied beyond standard clinical care.

Graft Failure and Consequences of Coronary Artery Bypass Graft Surgery

Coronary artery bypass graft (CABG) surgery is the commonest type of heart operation performed. During this, arteries or veins (termed 'grafts') are used to supply blood around blockages within the blood vessels that supply the heart. Unfortunately, these grafts can sometimes fail, and patients can also experience complications like heart attacks and strokes, after surgery. It is known that vein grafts are more likely to narrow over time. Additionally, treating vein graft failure is very challenging, as repeat surgery is riskier and procedures to stent open the veins can also fail. However, it is not fully understood why these complications occur. In this study, the investigators will use an imaging technique called a total-body Positron Emission Tomography (PET) scan. This uses special radioactive dyes (radiotracers) to look at what is happening inside vein grafts. With this technique, the investigators will also be able to see what is happening to the heart, brain and wider parts of the body after CABG surgery. This study will aim to recruit 70 participants in total (maximum 150). 40 (maximum of 120) of these participants will have recently undergone CABG surgery and received ≥1 vein graft. The remaining 30 will have undergone CABG surgery ≥5 years ago and will have symptoms suggestive of vein graft failure. The study will last a total of 36 months and will involve participants undertaking the following assessments: 1. Total-body Positron Emission Tomography and Computed Tomography (PET-CT) scan 2. Ultrasound scan of the heart (echocardiogram) 3. A blood test - up to four tablespoons (60 mL) of blood will be taken for immediate testing and the remainder will be stored for future ethically approved studies.

Examining the Effects of Video-Assisted Discharge Education After Coronary Artery Bypass Graft Surgery on Patient Satisfaction and Anxiety

This study was conducted to examine the effects of standard and individualized video-assisted discharge education on patient satisfaction and anxiety levels following Coronary Artery Bypass Graft (CABG) surgery. Prior to the initiation of the study, ethical approval was obtained from Hasan Kalyoncu University and the relevant healthcare institutions. The study was carried out with a total of 120 patients who had undergone CABG surgery and were hospitalized in the Cardiovascular Surgery departments of Gaziantep Dr. Ersin Arslan Training and Research Hospital and Gaziantep City Hospital. The patients were randomly assigned into three groups: a control group, a standard video-assisted education group, and an individualized video-assisted education group. Data were collected using the Patient Information Form, the Patient Education Satisfaction Scale, and the State-Trait Anxiety Inventory (STAI). The data were analyzed using SPSS version

Determining the Consistency Between Nurses and Artificial Intelligence (ChatGPT-5) in Delivering Scenario-Based Discharge Education to Coronary Artery Bypass Graft Patients: A Methodological Study

This methodological study aims to determine the level of agreement between nurses and an artificial intelligence system (ChatGPT-4.0) in providing scenario-based discharge education for patients who have undergone coronary artery bypass graft (CABG) surgery. Thirty standardized patient scenarios representing different demographic, clinical, and psychosocial characteristics will be used. For each scenario, both expert nurses and ChatGPT-4.0 will prepare discharge education content based on six main domains and twenty-four subtopics identified from the literature and clinical guidelines. The educational materials will be independently evaluated by two blinded reviewers in terms of content accuracy, completeness, scientific consistency, and clarity of language. Agreement between nurses and AI-generated content will be analyzed using Cohen's Kappa coefficient and Fisher's Exact Test. The findings are expected to provide evidence for the reliability and applicability of AI-assisted discharge education systems in cardiac surgery nursing practice.

Progressive Relaxation Exercises Before Mobilization:Effects on Pain, Anxiety and Physiologic Parameters CABG Patients

This study is planned as a randomized controlled experimental study to determine the effect of progressive relaxation exercises applied before mobilization on pain, anxiety and physiological parameters in patients undergoing coronary artery bypass graft surgery.

Association Between μFR And CABG Outcomes

The goal of this observational study is to evaluate the association between Murray law-based quantitative flow reserve and outcomes after coronary artery bypass graft surgery.