Clinical Research Directory

Differences In Microbiota Profiles Of Pediatric Appendicitis Cases

The microbial profile varies between simple appendicitis (SA) and complicated appendicitis (CA) cases. An appendectomy has been noted to temporarily diminish gut bacterial diversity. Changes in the microbial profile associated with appendicitis are known to significantly influence the development of acute appendicitis (AA). Therefore accurately distinguishing between SA and CA cases is essential for selecting suitable treatment approaches. The aim of this clinical study is to determine whether the gut bacterial profile plays a role in cases of simple and severe appendicitis in pediatric patients. Healthy volunteers will also be included in the study for the purpose of comparing results. The key questions the researchers aim to answer are: Are there differences in the biochemical values of participants with simple versus severe appendicitis? Are there differences in the gut bacteria present in cases of simple versus severe appendicitis? There are no specific procedures or requirements for the participants or healthy volunteers to follow. There will be no changes to their treatment or medical care.

Limosilactobacillus Fermentum CRL 1446 - CONICET CASASCO

This research study aims to determine if a probiotic called Limosilactobacillus fermentum CRL 1446 can improve the health of people at risk for cardiovascular disease. The study will be conducted with volunteers who will randomly consume either the probiotic or a placebo (a capsule without the probiotic), without knowing which one they are taking. The researchers will analyze how the probiotic affects blood sugar control, body composition, inflammation, and oxidative stress. The goal is to determine if this beneficial bacterium, by influencing the gut microbiota, could be a new strategy to prevent or mitigate chronic heart diseases.

Microbiota as Early Diagnostic and predictivE Factor for Osteoarthritic Degeneration and Microbial Contamination

The patient(s) will participate in a clinical study that aims to investigate how the gut microbiota may influence the proper functioning of joints in the body and how it may affect the development of early osteoarthritis (OA), periprosthetic joint infection (PJI), and recovery after total joint replacement. In particular, the prevalence of early OA among patients with gut dysbiosis will be studied (Objective 1). The aim is to identify gut dysbiosis as a potential diagnostic factor for early OA. The study will analyze knee MRI scans and shoulder ultrasound images of 40 patients without musculoskeletal symptoms but with confirmed gut dysbiosis.In addition, the intra-articular microbiota in 50 patients undergoing total knee replacement will be investigated. Serum LPS levels during surgery and fecal microbiota before surgery and during postoperative recovery will be assessed (Objective 2). Postoperative recovery will be assessed based on criteria such as time off crutches and subjective scores. Finally, this will explore the correlation between gut microbiota and contaminating germs in periprosthetic infections. (Objective 3). 40 patients undergoing joint revision surgery for septic failure of a knee or hip replacement and 40 patients undergoing revision surgery for aseptic loosening for PJI will undergo gut microbiota analysis. Comparison between the two groups will allow evaluation of whether PJI causes changes in the gut microbiota. The patients will be included in the study under * objective 1 * objective 2 * objective 3