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Tundra lists 2 Drug Refractory Epilepsy clinical trials. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.
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NCT07012148
Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables
The purpose of this study is to evaluate the safety and feasibility of using seizure forecasts based on subscalp EEG.
Gender: All
Ages: 18 Years - 75 Years
Updated: 2026-03-19
1 state
NCT06292494
Focused Ultrasound for Drug-resistant Epilepsy
Focused ultrasound (FUS) has been shown to differentially lesion or modulate (excite and inhibit) brain circuit and neural activity across a broad range of acoustic stimulus parameters (intensity, duty cycle, pulse repetition frequency and pulse duration) for decades. From our previous study, FUS sonication may suppress the number of epileptic signal bursts observed in EEG recordings after the induction of acute epilepsy. The presence of the suppressive effect was found in terms of the number of epileptic EEG spikes from the analysis of the unfiltered and theta-band EEG activity, and further discontinue the seizure attacks. EEG activity has also been consistently reported to have a positive correlation with the level of epilepsy, and FUS-mediated reduction of epileptic EEG activity was most notably observed, no matter lesioning or modulating effects. The aims of this study are to demonstrate the safety and efficacy of FUS technology in epilepsy patients and to estimate the optimal parameters of focused ultrasound exposure that will be used in the case of epilepsy.
Gender: All
Ages: 18 Years - Any
Updated: 2025-09-09