Clinical Research Directory

Effect of Protein on Endoplasmic Reticulum Stress

This study was planned to provide information about the effect of short-term high protein diet (HPD) feeding on endoplasmic reticulum stress. The definition of HPDs cannot be determined exactly. They are defined differently by various scientific authorities. However, the target is for protein to be approximately 30% of total energy in HPD. It has been determined that HPDs increase satiety, thermogenesis, and provide body weight loss and maintenance of loss. In general, there is evidence that HPDs provide more body weight loss in a short time compared to low protein diets. It has been emphasized that the effect of high protein diet on weight loss is related to creating satiety, thus reducing food intake and increasing thermogenesis. However, the physiological, biochemical and molecular events that occur due to HPD feeding are not fully understood and the results have not been explained. It has been determined that the effects of HPDs last between 1 and 6 days and 6 months. The absence of any study in the literature on the short-term and long-term effects of HPD on oxidative events in humans reveals the original value of this study. Therefore, considering that long-term HPD feeding may increase the risk of cardiovascular disease, blood pressure and blood lipid levels, the effect of short-term HPD feeding on endoplasmic reticulum stress will be investigated in order to avoid these side effects. Blood analyses planned for this prospective analytical study will be performed in GENKÖK Laboratory. Healthy individuals will be administered 10 days of HPD and a 10-day normal diet as a control.