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Electrical Status Epilepticus of Slow-Wave Sleep

Tundra lists 1 Electrical Status Epilepticus of Slow-Wave Sleep clinical trial. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.

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COMPLETED

NCT04721691

Efficacy of Epidiolex in Patients With Electrical Status Epilepticus of Sleep (ESES).

This study aims to assess the efficacy of Epidiolex in patients with ESES. ESES is characterized by sleep potentiated spikes with a spike index greater than 85% (conventional definition) and 50% (new definition)1. Several drugs including: steroids, intravenous Gama globulin, Clobazam, other benzodiazepines, Valproic acid, and other anti-epileptic drugs have been tried with mixed benefits2,3. Cannabidiol (CBD) would provide a novel mechanism of action to assess for its efficacy in this population. This will be a double-blind placebo-controlled crossover clinical trial.

Gender: All

Ages: 2 Years - 17 Years

Updated: 2026-08-28

1 state

Electrical Status Epilepticus of Slow-Wave Sleep