Clinical Research Directory

Predictors of Successful Office Operative Hysteroscopy Using a Mini-Resectoscope

The goal of this observational study is to identify predictors of successful removal of benign intrauterine pathology using a mini-resectoscope during office operative hysteroscopy without anesthesia in adult women with suspected or diagnosed endometrial polyps or retained products of conception up to 2.5 cm in size. The main questions it aims to answer are: * Which demographic, gynecologic, clinical, and hysteroscopic factors are associated with successful completion of office operative hysteroscopy using a mini-resectoscope without anesthesia? * Which factors are associated with severe pain during the procedure, defined as a Visual Analog Scale (VAS) score greater than 7? * Is prolonged procedure duration (\>3 minutes) associated with higher intraoperative pain scores? * Are there differences in success rates between procedures performed for endometrial polyps versus retained products of conception? Participants will: * Undergo office operative hysteroscopy without anesthesia using the Miniresectoscope device for removal of endometrial polyps or retained products of conception. * Provide demographic, obstetric, gynecologic, and medical history information before the procedure. * Have intraoperative hysteroscopic and surgical characteristics recorded, including cervical stenosis, uterine orientation, lesion size and location, lesion morphology, and procedure duration. * Complete pain assessments using the Visual Analog Scale (VAS) during the procedure and 5 minutes after the procedure. * Be evaluated for procedural success, defined as complete removal of the intrauterine pathology.

Use of Nitrous Oxide During Office Hysteroscopy

The goal of this clinical trial is to assess the use of inhaled nitrous oxide during office hysteroscopy. The main questions it aims to answer are: * Does it reduce pain during the procedure? * Does it increase the success rate? * Does it improve patient satisfaction? * Does it reduce anxiety? * Which populations benefit more (e.g., parity, menopausal status, number of previous surgeries, type and duration of procedure, and type of device)? Participants will be asked about their pain levels during the procedure, as well as their anxiety levels. All responses will be recorded. Written informed consent will be obtained prior to initiation.

Cohort Study of Intrauterine Diseases

"This study employs a prospective cohort design by establishing a uterine cavity diseases research platform. The investigators will collect participants' current medical history, menstrual and obstetric history, past medical history, physical and gynecological examinations, imaging studies, laboratory tests, and pathological examinations. After the hysteroscopic surgery, the investigators will conduct a one-year follow-up on the disease progression of the participants. Through this comprehensive approach, the investigators aim to deeply investigate the pathogenesis, risk factors, and optimized treatment strategies for uterine cavity diseases."

Impact of Different Saline Pressures During Hysteroscopy on Visibility, Feasibility and Patients' Discomfort

Hysteroscopy is a minimally invasive diagnostic and therapeutic procedure for various intrauterine conditions. It is performed with an optic device while entering liquid media to the uterus to allow visualization. Diagnostic procedures are often performed without anaesthesia (in the office setting) and operative procedures are performed either under general anaesthesia or without anaesthesia (in the office setting). It depends on the patients' characteristics and preferences, and surgical indications. 80%-100% of operative procedure without anesthesia can be successfully completed. The main reasons for inability to successfully complete operative hysteroscopy without anesthesia are patients' discomfort and limited visibility of the uterine cavity. In the current study, the investigators will compare the use of two different pressure setting of the liquid media during operative hysteroscopy without anesthesia, with the aim of investigating the successful completion of the procedure and patient's discomfort, with the aim of determining the optimal pressure setting.