Clinical Research Directory

Why do People With Cerebral Palsy Often Feel Fatigued?

Persons with cerebral palsy (CP) commonly suffer from fatigue. Fatigue is an important cause of their reduced participation in work or social life. Traditionally, CP-related fatigue has been viewed as related to the person's motor impairment. This view causes habilitation efforts to focus on muscle function. We hypothesize that the feeling of being fatigued must involve the activity of a specific, but un-identified, brain network that represents this particular sensation. We will use electroencephalography (EEG) and 18F-2-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) in CP patients with fatigue of different degrees to identify difference in brain activity that can highlight the presumed 'fatigue network' in the brain. In this work, we build on experience from another study on fatigue in people that have had a brain abscess (see: Cognitive function and fatigue after brain abscess, NCT#: NCT04938362) Clarification of whether fatigue in CP has a muscular or cerebral cause will hopefully inform and improve habilitation efforts for this group, and it may single out fatigue as a separate treatment target.

Monitoring Fatigue In Daily Life In Adults With Cerebral Palsy or Acquired Brain Injury

The goal of this observational study is to learn about levels and patterns of fatigue in adults with cerebral palsy (CP) and acquired brain injury (ABI) in daily life. The main question it aims to answer is: How do adults with CP and ABI experience fatigue in daily life? Researchers will compare data from CP and ABI with healthy volunteers to see if they experience fatigue differently. Participants will: * Monitor their symptoms, mood, and behavior in real-time by completing a brief survey on their mobile phone 10 times a day for seven consecutive days. * Attend a briefing session the day prior to the seven-day period of real-time monitoring. * Wear an accelerometer for the seven-day period. * Complete a daily sleep diary for the seven-day period. * Receive feedback on their real-time monitoring data, sleep and activity data.

Myocene Sensivity to Cycling Intensities

This study aims to address this gap by assessing LFF following different efforts in cycling, aiming to identify a pattern. Also, we expect that this study helps to clarify to which efforts (prolonged vs short) are more likely to trigger substantial changes in LFF responses.

Influence of Acute Daily Workload Changes on Low-frequency Fatigue Morning Scores

In recent years, the increased demands of both training and competition have heightened the need of load monitoring among soccer players. However, adopting metrics that comprehensively capture the intricacies of neuromuscular fatigue remains a challenge. Assessing low-frequency fatigue may contribute to fill this gap, as it provides an objective measure to evaluate muscle function readiness. Thus, the aim of this study was to examine whether variability in low-frequency fatigue morning scores are related to training external load acute changes throughout the in-season microcycle.