Clinical Research Directory

Treatment of Tension-type Headache by Zhixuan Analgesic Tablets

The goal of this clinical trial is to learn if Zhixuan Analgesic Tablet works to treat frequent episodic tension-type headache in adults aged 18-60 years. It will also learn about the safety of Zhixuan Analgesic Tablet. The main questions it aims to answer are: * Does Zhixuan Analgesic Tablet reduce the number of headache days compared with placebo within each 4-week interval during the 12-week treatment period? * What medical problems do participants have when taking Zhixuan Analgesic Tablet? Researchers will compare Zhixuan Analgesic Tablet (4 tablets per dose, 3 times per day) to a matching placebo (a look-alike tablet that contains no active drug) to see if Zhixuan Analgesic Tablet reduces overall headache burden - including headache days, the amount of acute analgesic medication needed, the duration and severity of headaches, and the impact of headache on daily life. Participants will: * Take Zhixuan Analgesic Tablet or a matching placebo 3 times per day for 12 weeks * Keep a headache diary to record headache days, headache duration and severity, and any acute analgesic medication used * Attend scheduled clinic visits for check-ups and safety monitoring * Complete the Headache Impact Test (HIT-6) and a global self-assessment of treatment effectiveness at the end of the treatment period

Efficacy of a Multimodal Physiotherapy Program and Mobile-App Guided Meditation in Adults With Frequent or Chronic Tension-Type Headache

The goal of this clinical trial is to evaluate whether a multimodal physiotherapy program and guided meditation using a mobile app can help reduce headache pain and improve quality of life in adults with frequent or chronic tension-type headache. The study analyzes the effects of physical and psychological interventions applied both separately and in combination, so that the combined treatment addresses tension-type headache as a multifactorial condition influenced by biopsychophysiological factors, integrating physical and psychological strategies to improve participants' overall well-being. The main questions it aims to answer are: * Does multimodal physiotherapy lower the intensity and frequency of headaches? * Does guided meditation through a mobile app help reduce stress and improve emotional well-being? * Are the combined effects of physiotherapy and meditation greater than either intervention alone? The study will compare: * A group receiving multimodal physiotherapy sessions once a week for four weeks, * A group practicing guided meditation with a mobile app for about 5 to 7 minutes daily, * A group combining both physiotherapy and meditation. Participants will: * Attend clinical sessions or use the meditation app depending on group assignment, * Complete short questionnaires about pain, stress, sleep, and daily functioning, * Record headache episodes in a structured diary during the study period.