Clinical Research Directory

Browse clinical research sites, groups, and studies.

1 clinical study listed.

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GPC3 Gene Inactivation

Tundra lists 1 GPC3 Gene Inactivation clinical trial. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.

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RECRUITING

NCT03198546

GPC3-CAR-T Cells for Immunotherapy of Cancer With GPC3 Expression

The third/fourth generation of CAR-T cells that target GPC3 (GPC3-CART cell) and/or soluble TGFβ (GPC3/TGFβ-CART )have been constructed and their anti-HCC function has been verified by multiple in vitro and in vivo studies. Clinical studies will be performed to test the anti-cancer function by the GPC3/TGFβ-CAR-T cells in human HCC patients with GPC3 expression. In this phase I study, the safety, tolerance, and preliminary efficacy of the GPC3/TGFβ-CAR-T cell immunotherapy on human will firstly be tested.

Gender: All

Ages: 18 Years - 75 Years

Updated: 2024-06-25

1 state

Hepatocellular Carcinoma

Immunotherapy

CAR