Clinical Research Directory

Telephone-Based Care Coordination for Services Addressing Childhood Adversity

The goal of this study is to learn how telephone-based screening and care coordination impacts children experiencing adverse childhood events (ACEs). The main questions are: 1. Does telephone-based screening and care coordination for children experiencing ACEs increase child receipt of ACEs-related services? 2. Does telephone-based screening and care coordination for children experiencing ACEs improve parent health and wellbeing? 3. Does telephone-based screening and care coordination for children experiencing ACEs improve child social and emotional health? Researchers will compare families who have been randomly selected to receive telephone-based screening and care coordination with those who will receive usual care at their clinic. Participants will: * Be randomly assigned to receive usual care or usual care plus telephone-based screening and care coordination (the intervention) * If selected for the intervention, be connected to 211 Los Angeles to receive screening and care coordination for up to 6 months * Complete four surveys via interview; surveys will be done at enrollment and 1 month, 6 months, and 12 months following enrollment * Agree to allow researchers to review their child's medical records to collect information about their child's health, screenings, diagnoses, and referrals.

BASIS Optimization

The objective of the BASIS R34 pilot study is to test the impact of eBASIS in a randomized controlled trial (RCT). Consistent with IMPACT's IQM, the study tests effects of eBASIS on treatment fidelity and youth outcomes, compared to a digitally delivered control (N=32 clinicians; 96 clients). A well-established EBP (Cognitive Behavioral Therapy Plus), will be a focus of the investigation, which eligible participants will already be signed up to receive.

Effects of Donor-recipient Sex-matched Blood Transfusion on Patient Outcomes

Red blood cell (RBC) transfusions are selected based upon matching donor and recipient blood group: donor and recipient sex are not considered when selecting blood for transfusion. Hence, transfused patients can currently receive sex-matched and/or unmatched RBCs when transfusions are given. Sex-matched stem cell transplants, and some solid organ transplants, have shown that sex-matching donor to recipient improves patient outcomes. Recent exploratory studies have also suggested that patient outcomes could be improved by sex-matching for RBC transfusion. There is emerging evidence of underlying biologic mechanism(s) to support these observations. This study is designed as a randomized controlled trial and will explore the impact on patients who receive RBC transfusions from donors of the same sex ("sex-matched") compared with donors of the opposite sex ("sex-mismatched"). The trial will study adult patients admitted to the Intensive Care Unit who require an RBC transfusion. Patients will be assigned (through a process called randomization) to receive sex-matched RBCs or sex-mismatched RBCs to determine if there is a difference in mortality between those receiving matched versus mismatched RBCs. The results of this trial could have direct implications on resources, blood inventory, and RBC transfusion ordering practices.