Clinical Research Directory

CHECK-NIRS2D-Study

The study investigates how external, physiological, and behavioral factors influence the measurement of regional tissue oxygenation using two-dimensional near-infrared spectroscopy (NIRS) imaging in healthy volunteers. It aims to improve the standardization and reliability of this non-invasive method for assessing microvascular perfusion and tissue oxygenation. The study also examines the effects of temporary vascular occlusion, ambient temperature, physical activity, caffeine consumption, and nicotine consumption on NIRS-based tissue oxygenation measurements. The findings are intended to establish a standardized measurement protocol for future clinical research and the assessment of microvascular perfusion in critically ill patients.

Acute Effects of Thoracolumbar Fascia Myofascial Release on Cortical Activity

This study will examine the immediate (acute) effects of a single myofascial release technique applied to the thoracolumbar fascia on brain activity in healthy young adults aged 18-25. Using a sham-controlled, randomized design, participants will be assigned to either an active treatment group, receiving a 10-minute myofascial release technique to the lower back, or a sham control group, receiving light surface touch to the same area for the same duration without any therapeutic pressure or movement. Brain activity will be recorded using a portable, 8-channel wireless EEG system before the intervention, shortly after it (0-10 minutes), and again 30 minutes later, allowing researchers to track how cortical activity changes over time. Measurements will focus on sensorimotor rhythms (mu rhythm) and posterior alpha power, along with heart rate variability, to assess whether the myofascial technique produces effects that go beyond those of simple touch. The main goal is to determine whether this hands-on technique produces a measurable, distinct pattern of brain activity compared to a sham (placebo-like) touch condition.

Feasibility of an Augmented Reality Novel Approach for the Rehabilitation of Chronic Low Back Pain Patients With Kinesiophobia

The goal of this clinical trial is to evaluate the feasibility, safety, and initial effectiveness of a new augmented reality (AR) system in adults over 18 years old suffering from chronic low back pain and kinesiophobia (fear of movement). The main questions it aims to answer are: Is the AR system safe to use and well-tolerated by participants without causing significant motion sickness or discomfort? Can the visual "illusion" provided by the AR technology help patients increase their range of motion and reduce their fear of bending forward? Participants will: * Perform 10 to 12 repetitions of spinal bending exercises while wearing an AR headset that shows a video of them moving further than they actually are. * Complete questionnaires regarding their pain levels, physical disability, and fear of movement. * Report any symptoms of "cybersickness" (like dizziness or nausea) experienced during the use of the technology. * Participate in a brief interview to discuss their experience, how they felt using the device, and provide suggestions for improvement.

Online Medical Hypnosis Exercises to Improve Mental Health in Primary School Children and Prevent Future Mental Health Issues

The goal of this trial is to learn if listening daily to online hypnosis exercises helps to improve mental health and self-esteem in primary school children. In the future we also hope to see if it can prevent feelings of depession or anxiety when these children have become teenagers. The main questions it aims to answer are: 1. can daily listening to these exercsies improve self-esteem, resilience and mental health of children 10-11 years compared to children who do not listen to these exercises? 2. can listening to these exercsies prevent future metal health problems like feelings of depression or anxiety. Researchers will compare a group of children (10-11 years) who will listen daily to the exercises for 2 months with a group who will do that 6 months later. Participants will: Listen daily to a hypnosis exercise of maximum 15 minutes. Fill out questionnaires on self-esteem, resilience and mental health before during and after the study.

The Effect of Two Different Exercise Programs in Young Sailors

This study aims to investigate the effects of an 8-week structured land-based exercise program on hiking endurance, core endurance, muscle activation, balance, and motor competence in young sailors. The intervention will be applied in addition to a standard hiking bench training, which simulates the physically demanding "hiking" maneuver used in sailing. A total of 26 adolescent athletes, aged 12 to 18 years, will be randomly assigned to two groups: one receiving hiking bench training only, and the other receiving hiking bench training combined with structured strength, flexibility, balance, and dynamic warm-up exercises. Evaluations will include endurance testings, electromyography (EMG) analysis of muscle activity, balance tests, and motor coordination assessments. The results are expected to inform future training programs by optimizing athletic performance and supporting injury prevention strategies in youth sailing.