Clinical Research Directory

The Effect of a Virtual Reality Video Intervention

This randomized controlled trial aims to evaluate the effect of a virtual reality (VR) video intervention on fear of childbirth and anxiety among hospitalized high-risk pregnant women receiving bed rest. High-risk pregnancy and prolonged hospitalization may increase psychological distress, including fear of childbirth and anxiety. Virtual reality has emerged as a non-pharmacological distraction technique that promotes relaxation by immersing individuals in calming virtual environments. Participants in the intervention group will watch a nature-themed VR video with relaxing sounds using a VR headset in addition to routine care, while the control group will receive routine care only. The findings may provide evidence for the use of VR as a supportive nursing intervention to improve the psychological well-being of hospitalized high-risk pregnant women.

UCLA Perinatal Biospecimen Repository

The purpose of this investigator-initiated prospective observational cohort study is to establish the new UCLA Perinatal Biospecimen Repository (Perinatal Repository) for collection, storage, and distribution of the human data and biospecimens of the participants with perinatal pathology. The secure and shared high-quality resource of clinical data and biological specimens (Repository Materials), across pregnancy pathology related to research protocols at the Afshar's Lab will be created. Core variables of interest include clinical characteristics and relevant biological samples. Intention to collect perinatal data is aiding the efficiency and effectiveness of de-identified biorepository for pregnancy-at-risk outcome research. The primary aims of the project are: * To design the Case Report Forms (CRFs) for the clinical and biospecimen data. * To create and update the project-specific policies, agreements, and Standard Operating Procedures (SOPs). * To develop the data management system to assure personal health information de-identification, data integrity, participants welfare, and protocol compliance. * To develop and implement a quality management system for the Repository. * To collect and record in the Repository protocol-related clinical information. * To organize a consistent system to bank high-quality biospecimens while protecting participant-donor safety and privacy. * To establish the policies and procedures for Repository Materials dissemination and research collaboration. * To analyze the scientific results of the Repository creation. The secondary aim of the study is to provide a mechanism to store and share for research purposes the de-identified biospecimen and information about participants at risk for adverse pregnancy outcomes.