Clinical Research Directory

Risk of Scrotal Hydroceles After Nephrectomy For Kidney Cancer

This population-based study will use provincial health administrative data to examine the risk of hospital admission for hydrocelectomy among males who underwent nephrectomy for kidney cancer, compared with males from the general population with similar baseline health characteristics, who did not undergo nephrectomy. We will use health administrative data from Ontario, Canada, to identify males who underwent nephrectomy for kidney cancer between 2002 and 2024. Four surgical cohorts will be constructed based on procedure type and surgical approach: laparoscopic total nephrectomy, open total nephrectomy, laparoscopic partial nephrectomy, and open partial nephrectomy. A propensity score will be calculated based on sociodemographic characteristics, comorbidities, and health care utilization. For each surgical cohort, patients will be matched to non-nephrectomy male controls (1:4) based on propensity score, age, index date, and modified Charlson Score (excluding cancer). The primary analysis will compare patients undergoing laparoscopic total nephrectomy and laparoscopic partial nephrectomy with matched non-nephrectomy controls from the general population. The primary outcome is hospital admission for hydrocelectomy. Secondary outcomes include diagnosis of hydrocele with receipt of a scrotal ultrasound, and receipt of a scrotal ultrasound. Additional analyses will compare surgical approaches.

Risk of Hydroceles Following Pyeloplasty

This population-based study will use provincial health administrative data to examine the risk of hospital admission for hydrocelectomy among males who underwent laparoscopic pyeloplasty, compared with males from the general population with similar baseline health characteristics. We will use health administrative data from Ontario, Canada, to identify males who had a laparoscopic pyeloplasty between 2002 and 2024. We will calculate a propensity score based on sociodemographic characteristics, comorbidities, and health care utilization. We will then match laparoscopic pyeloplasty males to non-pyeloplasty male controls (1:10) based on propensity score, age, and index date. The primary outcome is hospital admission for hydrocelectomy. The secondary outcomes are a hydrocele diagnosis and receipt of a scrotal ultrasound.