Clinical Research Directory

Goal-Directed Temperature Management During Prolonged Abdominal Surgery

During long operations on the abdomen, patients often get cold. Doctors call this perioperative hypothermia. Even a small drop in body temperature can cause problems, such as more bleeding, wound infection, and a longer stay in hospital. To keep patients warm during surgery, doctors usually blow warm air over the body through a special blanket. However, the fluids that patients receive through a vein during surgery are normally at room temperature. These cool fluids may lower the body temperature from the inside. This study compares two ways of keeping patients warm during operations on the abdomen that last three hours or longer. Everyone taking part receives warm air blown over the body. In addition, one group receives fluids into a vein at room temperature, about 23 °C, which is the usual practice. The other group receives the same fluids warmed to 39 °C by a special device just before the fluid enters the vein. Participants are placed into one of the two groups by chance, like flipping a coin. Because of the nature of the treatment, the doctors caring for the patient know which group the patient is in. The researchers measure body temperature before, during, and at the end of surgery. They also record blood pressure, the medicines used to support blood pressure, the amount of fluid given, the amount of urine produced, and blood tests taken on the day after surgery. This is a pilot study. Its main purpose is to find out whether a larger study would be possible. The researchers want to learn how many patients can be enrolled, whether the treatment can be given exactly as planned, and how complete the collected information is. The results will be used to plan a larger study.

Study of the Prevalence of Postoperative Hypothermia in Adults Undergoing Non-Cardiac Surgery in Spanish Post-Anesthesia Care Units

The prevalence of Hypothermia in Spanish Post-Anesthesia Recovery Units (in Spanish: "Prevalencia de Hipotermia en las Reanimaciones Españolas" PHRES Study) is a prospective, multicenter observational study that will evaluate how often adults develop unintended low body temperature after non-cardiac surgery in post-anesthesia recovery units in Spain. Unintended low body temperature, known as perioperative hypothermia, is a common problem after surgery and may be associated with complications such as shivering, increased bleeding, heart problems, discomfort, and delayed recovery. Although active warming devices and temperature monitoring are available in many Spanish hospitals, their use may vary between centers. The study will include adults undergoing scheduled non-cardiac surgery lasting more than 60 minutes under general, regional, or combined anesthesia. Approximately 1,334 patients from 25-30 Spanish hospitals are expected to participate. Patients will be included consecutively according to predefined eligibility criteria. The study will record information about the patient, the type and duration of surgery and anesthesia, and the measures used to prevent low body temperature before and during surgery, including active warming and temperature monitoring. On arrival in the post-anesthesia recovery unit, the patient's core body temperature will be measured using the same non-invasive temperature monitoring technology in all participating centers. The main objective is to determine the proportion of patients with a core temperature below 36°C at the time of admission to the recovery unit. The study will also investigate factors associated with postoperative hypothermia and record complications occurring shortly after surgery, such as shivering, hemodynamic instability, new-onset arrhythmias, significant bleeding, and the need for blood transfusion. This is an observational study. The study will not determine or change how patients are warmed or how their temperature is monitored during surgery. These decisions will remain the responsibility of the treating anesthesia team according to local clinical practice. The additional temperature measurement performed for the study is non-invasive and does not involve any significant additional risk to participants.

Incidence and Risk Factors of Intraoperative Hypothermia in Adult Patients After Protocol Implementation

Inadvertent intraoperative hypothermia is one of the most common complications in patients undergoing anesthesia. This condition is strongly associated with several adverse clinical. At Siriraj Hospital, a previous study revealed a high incidence rate of 74.4%, with only 16.3% of patients receiving intraoperative temperature monitoring. In response to these findings, Siriraj Hospital implemented a perioperative temperature management guideline in July 2024. However, it remains to be evaluated whether the implementation of this protocol has led to a meaningful change in clinical practice. The primary concern is whether the adherence to temperature monitoring for surgeries exceeding one hour has improved from the historical rate of 16.3%, and subsequently, whether this has resulted in a decreased incidence of hypothermia.

The Effect of Heating the Intensive Care Room in the Early Postoperative Period on Patient Outcomes

The aim of this study was to evaluate the effect of heating the intensive care room in the early postoperative period on patient outcomes.

Comparison of the Effect of Prewarming on Intraoperative Hypothermia in Patients Undergoing Holmium Laser Prostatectomy

This study aims to evaluate the effectiveness of prewarming methods in preventing intraoperative hypothermia in patients undergoing HoLEP surgery. Designed as a randomized controlled study, patients who receive prewarming will be compared with those in the control group.

Evaluation of The Relationship Between Perioperative Hypothermia and Emergence Agitation

The main aim of our study was to investigate the relationship between perioperative hypothermia and postoperative emergence agitation.