Clinical Research Directory

Predictors of Successful Office Operative Hysteroscopy Using a Mini-Resectoscope

The goal of this observational study is to identify predictors of successful removal of benign intrauterine pathology using a mini-resectoscope during office operative hysteroscopy without anesthesia in adult women with suspected or diagnosed endometrial polyps or retained products of conception up to 2.5 cm in size. The main questions it aims to answer are: * Which demographic, gynecologic, clinical, and hysteroscopic factors are associated with successful completion of office operative hysteroscopy using a mini-resectoscope without anesthesia? * Which factors are associated with severe pain during the procedure, defined as a Visual Analog Scale (VAS) score greater than 7? * Is prolonged procedure duration (\>3 minutes) associated with higher intraoperative pain scores? * Are there differences in success rates between procedures performed for endometrial polyps versus retained products of conception? Participants will: * Undergo office operative hysteroscopy without anesthesia using the Miniresectoscope device for removal of endometrial polyps or retained products of conception. * Provide demographic, obstetric, gynecologic, and medical history information before the procedure. * Have intraoperative hysteroscopic and surgical characteristics recorded, including cervical stenosis, uterine orientation, lesion size and location, lesion morphology, and procedure duration. * Complete pain assessments using the Visual Analog Scale (VAS) during the procedure and 5 minutes after the procedure. * Be evaluated for procedural success, defined as complete removal of the intrauterine pathology.

Surgical and Obstetric Outcomes in Patients With Uterine Malformations Undergoing Hysteroscopic Corrective Treatment

The goal of this observational cohort study is to learn if hysteroscopic correction can improve reproductive outcomes in women with uterine malformations. The main questions it aims to answer are: Primary hypothesis: -Does hysteroscopic correction significantly improve pregnancy rates at 12 months post-surgery in women with uterine malformations? Secondary hypotheses: * Does hysteroscopic correction significantly reduce the rate of first and second-trimester spontaneous abortions? * Does hysteroscopic correction significantly increase the live birth rate? * In symptomatic patients, does hysteroscopic correction significantly reduce dyspareunia and dysmenorrhea? * Which patient, histopathological, and surgical factors are associated with improved obstetric outcomes? Researchers will compare obstetric outcomes (pregnancy rate, spontaneous abortion rate, live birth rate, and symptom severity) before and after hysteroscopic correction to determine the effectiveness of this surgical intervention. Participants will be women with uterine malformations who underwent hysteroscopic correction at the Digital Hysteroscopy Center of Policlinico Universitario A. Gemelli di Roma and Azienda Ospedaliera Universitaria Federico II di Napoli. Data will be retrospectively collected and analyzed to assess the impact of surgery on reproductive outcomes.