Clinical Research Directory

siRNA Microneedle Patches for Ear Keloid Post-Surgical Scars

The goal of this clinical trial is to evaluate whether small interfering RNA (siRNA) microneedle patches can improve the scar appearances of ear keloids treated with surgery. The main questions it aims to answer are: * Do siRNA microneedle patches improve post-surgical scar appearance? * Do siRNA microneedle patches improve keloid-related symptoms, recurrence, usability, and tolerability? Researchers will compare standard treatment with CO₂ laser surgery followed by steroid injection with and without siRNA microneedle patches to see if the patches work to improve scar appearance. Participants will: * Undergo CO₂ laser ablation of an ear keloid. * Be randomly assigned to receive steroid injections alone every month for four doses, or to receive both steroid injections and siRNA microneedle patches. * Visit the clinic at regular intervals for check ups and tests including photography.