Clinical Research Directory

Long-Term Risk of Kidney Stones in Living Kidney Donors

Using a population-based, matched, retrospective cohort approach, this study will evaluate the long-term risk of kidney stones among living kidney donors compared with matched healthy nondonors. Linked administrative health care databases from Ontario, Alberta, and British Columbia will be used and living kidney donors who donated between 1992 and 2024 will be identified and matched 1:10 to a carefully selected population of healthy nondonors based on baseline characteristics. The primary outcome is a surgical intervention for kidney stones (including shockwave lithotripsy, ureteroscopy or percutaneous nephrolithotomy). The secondary outcome is a hospital encounter with a kidney stone diagnosis.

Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones

Kidney stones affect 1 in every 11 people in the US each year. In patients with kidney stones who are prescribed medications for stone management, only 30.2% are adherent to a medication regime and even fewer, only 13.4 % are adherent with citrate medications. Prescription potassium citrate can be expensive for many patients, leading to non-compliance. Sodium bicarbonate is a potential medication alternative that is cheaper and can potentially alkalinize the urine and/or decrease the risk of future kidney stones. However, efficacy of alternatives to potassium potassium citrate are not well studied. This study seeks to evaluate sodium bicarbonate and assess its ability to alkalinize urine in a cohort of patients with kidney stones and compare this to prescription potassium citrate.

The Use of AR / VR in Patients Presenting to the ED With Renal Colic

Utilization of VR / AR Calming as an adjunct to pharmacologic pain management for Renal Colic in Emergency Department Patients