Clinical Research Directory

Biofeedback Training Targeting at Knee Proprioception

The goal of this clinical trial was to learn if a localized knee exercise program with visual and auditory feedback improves joint awareness (proprioception) and movement quality in young adults with a history of knee injuries. It also evaluated the feasibility and safety of performing these exercises. The main questions it aimed to answer were: 1. Does targeted knee training with instant audio and visual warnings improve joint position awareness and decrease movement fear? 2. Is a supervised laboratory biofeedback training program more effective at improving knee function and movement consistency than an independent home training program? 3. How reliable is a manual goniometer compared to an isokinetic machine when measuring joint position errors? Researchers used a crossover design where every participant completed both the home-based training program and the laboratory-based biofeedback program, separated by a two-week rest period, to compare the effectiveness of the two approaches. Participants did: 1. Complete two separate three-week training blocks (two sessions per week) performing squats, lunge patterns, and sidesteps. 2. Attend testing sessions at the lab before and after each training block to evaluate balance, movement consistency, and joint position awareness. 3. Wear smart shoe insoles and surface body sensors during testing and laboratory training to track force and joint angles. 4. Keep a log of exercises and note any side effects when training independently at home.

Investigating the Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee Osteoarthritis

This Phase I/II randomized clinical trial investigates the safety, feasibility, and early regenerative potential of intra-articular administration of mesenchymal stem cell (MSC)-derived secretome combined with Plasma Rich in Growth Factors (PRGF) in patients with knee osteoarthritis (KOA). The study aims to assess whether this cell-free, biologically enriched therapeutic combination can reduce pain, improve joint function, and promote cartilage repair.

Comparison of Quadriceps and Semitendinosus Grafts in ACL Reconstruction Using Data From the Danish Knee Ligament Reconstruction Registry (DKRR)

This study looks at two different types of tendon (tissue) used in knee surgery to repair a torn anterior cruciate ligament (ACL), which is a common injury in active people. The two types are taken from different muscles in the thigh: one from the front (quadriceps) and one from the back (semitendinosus). We will use information already collected in a national health registry to see how patients recover after surgery. The study will compare knee function, activity level, and how often patients need another operation.