Clinical Research Directory

Effect of Custom Dynamic Orthoses on Forefoot Loading

The proposed study is designed to evaluate how foot loading changes during initial accommodation to a carbon fiber custom dynamic orthosis (CDO), after targeted training with or without visual feedback of foot loading, and after take-home use of the CDO. This study will quantify initial offloading associated with CDO use and determine if visual feedback of foot loading and additional take-home use of the CDO can further reduce forces, as orthotists work to provide CDOs to patients.

Association Between Pre-Season Physical Capacity and Injury Risk in Professional Soccer Players

This prospective observational study aims to investigate the relationship between pre-season physical capacities and lower-extremity injury risk during the competitive season in professional male soccer players. A total of 28 healthy professional male soccer players aged 18-35 years, with at least five years of training experience, will be included in the study. Participants will undergo comprehensive physical performance assessments during the pre-season period without being assigned to any experimental intervention or additional exercise program. Baseline assessments will include anthropometric measurements, countermovement jump (CMJ) performance, overhead squat assessment, aerobic fitness using the 30-15 Intermittent Fitness Test (30-15 IFT), eccentric hamstring strength using the NordBord system, and hip abduction and adduction strength using the GroinBar system. Inter-limb strength asymmetries will also be evaluated. Following the pre-season assessments, participants will be monitored for lower-extremity injuries during the competitive season. Injury information, including anatomical location, injury type, duration, and recurrence, will be collected from club physiotherapists and coaching staff. The primary objective is to examine whether pre-season physical performance characteristics, particularly hamstring strength, hip muscle strength, and inter-limb strength differences, are associated with subsequent lower-extremity injury occurrence. The findings may contribute to a better understanding of the relationship between pre-season physical capacity and injury risk in professional soccer and may help sports medicine professionals, physiotherapists, and strength and conditioning coaches identify relevant physical performance indicators for athlete monitoring.

TRiP-cast Score Validation and Evaluation of Adherence to Preventive Anticoagulant Treatment in Patients With Lower Limb Trauma Requiring Immobilization

This is a prospective, multicenter, observational cohort study designed to externally validate the Trauma-Related Immobilization-related Prophylaxis (TRiP(cast)) score in Tunisian adults with acute lower-limb trauma requiring immobilization and managed as outpatients. The study will assess the ability of the TRiP(cast) score to identify patients at increased risk of symptomatic venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism. A secondary objective is to evaluate adherence to prescribed thromboprophylaxis and to compare adherence between patients receiving low-molecular-weight heparin (LMWH) and those receiving direct oral anticoagulants (DOACs). Factors associated with treatment adherence, bleeding events, and thromboembolic outcomes will also be investigated. Patients aged 18 years or older with acute lower-limb trauma requiring immobilization for at least 7 days will be enrolled consecutively and followed prospectively. The decision to prescribe thromboprophylaxis and the choice of anticoagulant will remain entirely at the discretion of the treating physician according to routine clinical practice. Study investigators will not influence treatment decisions. The results are expected to provide external validation of the TRiP(cast) score in the Tunisian population and improve risk stratification and thromboprophylaxis management in ambulatory patients with lower-limb trauma.