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MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer

Tundra lists 1 MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer clinical trial. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.

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NCT04556253

AK104 in Locally Advanced MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer

This is a single-arm, multicenter phase II clinical study. The aim is to evaluate the safety, tolerability, and anti-tumor activities of AK104(a PD-1/CTLA-4 bispecific antibody) in MSI-H/dMMR locally advanced gastric adenocarcinoma and colorectal cancer during the perioperative period.Eligible patients will receive AK104 for three cycles before surgery and at most 6 months after surgery. The primary endpoint is the pathological complete response rate.

Gender: All

Ages: 18 Years - 70 Years

Updated: 2026-01-02

1 state

MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer