Clinical Research Directory

Effect of Serratus and Pectoralis II Plane Block Versus Pectoralis II Alone on Acute Postoperative Pain After Mastectomy

The goal of this randomized controlled clinical trial is to determine whether adding a serratus anterior plane block (SAPB) to a pectoralis II (PECS II) block improves pain relief and reduces the need for opioids in adult women undergoing breast removal surgery (mastectomy), with or without removal of lymph nodes from the armpit. The main questions it aims to answer are: 1. Does adding an SAPB to a PECS II block reduce the total amount of opioids needed in the recovery room and during the first 24 hours after surgery? 2. Does the combination reduce the amount of opioid pain medication needed during surgery? 3. Does the combination improve pain levels during the first 24 hours after surgery? 4. Does the combination affect the occurrence of side effects or complications, including nausea, vomiting, drowsiness, serious reactions to the local anesthetic, and collapsed lung? Researchers will compare a group receiving both SAPB and PECS II blocks with a group receiving only a PECS II block to determine whether the combination improves pain relief and reduces opioid requirements. Participants will: 1. Be randomly assigned to one of two groups, with both groups receiving general anesthesia for surgery. 2. Receive the assigned nerve block or blocks using ultrasound guidance and a local anesthetic medicine called ropivacaine. 3. Receive postoperative pain relief through a patient-controlled analgesia (PCA) device, which allows them to administer prescribed doses of morphine when needed, in addition to other pain medications. 4. Have their opioid use and pain levels assessed at scheduled intervals during the first 24 hours after surgery. 5. Be monitored for additional pain medication requirements, side effects, block-related complications, and changes in heart rate and blood pressure during surgery.