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Metastatic Malignant Neoplasm in Lymph Node

Tundra lists 1 Metastatic Malignant Neoplasm in Lymph Node clinical trial. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.

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TERMINATED

NCT04221438

Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement

This phase II trial studies how well encorafenib and binimetinib work before surgery in treating patients with BRAF V600-mutated stage IIIB-D melanoma that has spread to the lymph nodes. Encorafenib and binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. This trial also studies how well 18F-FLT positron emission tomography (PET)/computed tomography (CT) works in predicting the response of melanoma to encorafenib and binimetinib. 18F-FLT is an imaging agent, sometimes called a tracer. PET and CT are types of imaging scans. Using 18F-FLT PET/CT together with encorafenib and binimetinib may provide more information on melanoma over time.

Gender: All

Ages: 18 Years - Any

Updated: 2026-05-12

5 states

Melanoma of Unknown Primary

Metastatic Malignant Neoplasm in Lymph Node

Pathologic Stage IIIB Cutaneous Melanoma AJCC v8