Clinical Research Directory

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.

Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children

Multi-system Inflammatory Syndrome in Children (MIS-C) is a new condition related to COVID-19, the study investigators are still learning about its causes, effects, and long-term impact. "Long-Term Outcomes after the Multisystem Inflammatory Syndrome In Children", the Coronavirus MUSIC Study, is a research study funded by NIH and the National Heart, Lung, and Blood Institute. The study investigators hope to enroll at least 900 young people with MIS-C at children's medical centers in the U.S. and Canada. This research study will help us learn more about MIS-C and its effects on the long-term health of children.

Quality of Life in Children After Multisystem Inflammatory Syndrome in Children

The aim of this observational study is to assess whether Multisystem Inflammatory Syndrome (MIS-C) in children affects their quality of life. The investigators will examine whether there is a correlation between paediatric mortality prediction scoring systems, specific clinical and laboratory indicators, and whether some of these can predict the level of quality of life in children 24 months after hospital discharge. The primary questions are: Do children who survived MIS-C have a poorer quality of life 24 months after the illness compared to their peers? Can investigators identify prognostic indicators to create preventative strategies for MIS-C? The investigator will compare the quality of life in participants who survived MIS-C with a control group. The quality of life will be measured using a validated questionnaire. In the first phase, data from medical records will be collected. In the second, prospective part of the study, participants, healthy peers, and their parents or guardians will be asked to complete a questionnaire about quality of life.