Clinical Research Directory

Mangosteen Gel for Sunburn-Like Skin Redness Caused by Ultraviolet B Light

The goal of this clinical trial was to learn whether a gel made from mangosteen (Garcinia mangostana) fruit rind helps sunburn-like skin redness fade faster when it is applied after the redness has already appeared. The trial was conducted in healthy adult women with Fitzpatrick skin phototypes IV-V. The main questions it aimed to answer were: * Does mangosteen pericarp extract gel reduce skin redness (measured as the chromameter a\* value) more than a placebo gel between Day 1 and Day 3? * Which concentration of the gel (2.5%, 5%, or 10%) works best, and is the gel well tolerated? Researchers compared three concentrations of mangosteen gel with a placebo gel and with untreated skin, all on the same person's back. Participants: * Had six small test areas marked on the upper back * Had five of these areas exposed to a measured dose of narrowband ultraviolet B light to cause mild redness, while one area was shielded * Had the assigned gels applied twice daily on Days 1 and 2, starting 24 hours after light exposure * Had skin color measured with a chromameter on Day 1 and Day 3, and were checked for skin reactions at each visit