Clinical Research Directory

Mental Health and Innovation for French Higher-education Students

To fully grasp mental health, it is essential to understand and assess it by considering all the factors that affect it: family environment, school environment, emotional relationships, living conditions, social networks, etc. The symptom network approach takes into account a network of overlapping, multi-layered interactions. These networks evolve over time and are constantly mediated by other nodes, i.e., symptoms, which allows for the identification of markers (vulnerabilities or comorbidities) and the establishment of the dynamics of causal mechanisms. Mental health is thus a sum of stable states within a dynamic network structure of symptoms. Beyond determining prevalence, the SMILE project therefore aims for an analytical, network-based approach to symptoms of mental health and the inherent vulnerabilities of students through a self-administered questionnaire designed to examine various cognitive, emotional, social, and behavioral functions, and to address this new approach. The SMILE study could also help advance public health and identify the impact of university actions on the mental health of their own students.

Implementation-effectiveness Trial of Mainstreaming of Clinical Genomic Sequencing for Rare Disease in Ontario, Canada

Genomic sequencing (GS) is increasingly recommended as a diagnostic test for patients with suspected genetic disorders, but access often remains limited to those referred to medical geneticists. Enabling non-geneticist clinicians to access GS can expedite diagnoses for affected families and reduce burdens on the geneticist-led model of care. Targeted implementation strategies are needed to empower non-geneticist clinicians to access GS, however data to inform these strategies are lacking. To this end, the investigators have set out to carry out a prospective, hybrid implementation-effectiveness trial of mainstreamed clinical GWS in Ontario, Canada. The study team will evaluate the laboratory, clinical, patient and implementation outcomes of the mainstreamed model of care.

Ayres Sensory Integration Test Evaluation Results and Neurodevelopmentally Focused Counseling in Children With Neurodevelopmental Problems

The aim of the study is to investigate the long-term effects of ASI-based and hybrid neurodevelopmental counseling services on the variables of the Ayres Sensory Integration Assessment Test in children with neurodevelopmental disorders.