Clinical Research Directory

Effect of Single-Session HVPGS on Hand Grip Strength and Reaction Time in Healthy Individuals

The aim of this cross-sectional study is to investigate the immediate (acute) effects of a single session of High-Voltage Pulsed Galvanic Stimulation (HVPGS) on hand muscle strength and reaction time in healthy adults. A total of 42 healthy volunteers aged 18 to 65 years undergo a single session of HVPGS applied to the forearm flexor muscles (m. flexor digitorum superficialis, m. flexor digitorum profundus, and m. flexor pollicis longus). Isometric hand grip strength is evaluated before (T0) and immediately after (T1) the intervention using a Jamar hand dynamometer. Sensorimotor reaction time is measured at the same time points using the Nelson Hand Reaction Test. The study aims to determine whether acute HVPGS application elicits immediate bilateral enhancements in mechanical force production and central-mediated processing speed, and whether these gains interact with demographic factors or hemispheric hand dominance.

Eco-guided Neuromodulation of the Femoral Nerve on the Performance of Amateur Athletes.

This randomized crossover study aims to evaluate whether different percutaneous electrical nerve stimulation (PENS) protocols produce changes in neuromuscular performance in healthy adults. PENS involves the ultrasound-guided application of an electrical current through a needle to modulate motor neuron excitability. Each participant will undergo five intervention sessions: (1) a long-term potentiation (LTP)-based protocol with impulse trains, (2) a 10 Hz protocol with 10 s stimulation and 10 s rest repeated ten times, (3) a 5-55 protocol with 100 Hz stimulation for 5 s followed by 55 s rest repeated five times, (4) a high-intensity burst (HIB) protocol applied at a high current intensity close to 1000 mA and repeated three times, and (5) a placebo condition. All interventions will be applied bilaterally by an experienced physiotherapist under ultrasound guidance, with a two-week washout between sessions. The objective of this trial is to assess whether these stimulation patterns produce measurable changes in squat execution velocity, jump performance, and quadriceps strength. The findings may help identify the most effective stimulation strategy for enhancing neuromuscular performance.

"Muscle Strength, Balance, and Core Endurance in Elite Adolescent Rowers: A Cross-Sectional Study"

This study aims to investigate the relationship between lower extremity isokinetic strength, dynamic balance, and core muscle endurance in elite adolescent rowers aged 16-18. A total of 68 athletes (32 males, 36 females) will be assessed through standardized protocols involving isokinetic testing, the Y Balance Test, and McGill Core Endurance Tests. The study aims to contribute to performance monitoring and injury prevention strategies in rowing sports.

Acute Effects of Proprioceptive Neuromuscular Facilitation on Hamstring-to-Quadriceps Strength Ratio

This study aimed to compare the acute effects of proprioceptive neuromuscular facilitation (PNF) and static stretching on hamstring-to-quadriceps (H/Q) strength ratios in healthy young men. A randomized crossover design was used in which participants completed both stretching protocols on separate days. Isokinetic muscle strength and H/Q ratios were assessed following each intervention. The findings provide insight into the immediate effects of different stretching modalities on muscle balance and performance.

Exercise With Audible Cues on Motor Unit Behavior in Athletes With Anterior Cruciate Ligament Reconstruction

The closed kinetic chain (CKC) of terminal knee extension exercise (TKE) is designed to activate VM activity for knee injury training. This CKC exercise is effective for highest recruiting muscle activity, especially safe for post-operative knee surgery. The study of ACL reconstruction rehabilitation guideline suggests that exercises can be applied within the early phase of rehabilitation to prevent knee laxity and less knee pain compared to open chain exercise. Therefore, it is interesting to investigate the effects of TKE exercise synchronized with metronome pace on change of VM motor unit behavior in post operative ACL reconstruction. This study focuses on the immediate effect of 1-seesion TKE and expects that adding metronome during TKE will enhance neuromuscular control of VM and may change motor unit behavior.

Effect of 12-week Milk Fat Globule Membrane Supplementation on the Human Muscle Function of Healthy, Recreationally Active Adults

The main aim of this study is to understand if chronic supplementation (12 weeks) of a milk fat globule membrane containing supplement, called bioactive whey protein concentrate, improves human muscle function greater than a placebo supplement within a cohort of healthy, recreationally active adults. Furthermore, we aim to investigate whether any potential benefits of milk fat globule membrane are influenced by age through the assessment of 2 distinct age subgroups (young and older). We hypothesise that neuromuscular function (strength and power) will increase from pre to post within the group that consumes bioactive whey protein concentrate but not the placebo group, with a greater increase in the older group compared to the young group.

Impact of Menstrual Cycle-Based Resistance Training on Neuromuscular Performance in Female Athletes

The goal of this clinical trial is to assess the impact of menstrual cycle-based resistance training on neuromuscular function in female athletes. The primary questions it aims to answer are : * Does varying resistance training intensity according to menstrual phases improve maximal knee extensor strength? * How do different training protocols affect voluntary activation, rate of force development, muscle stiffness, and vertical jump height? Researchers will compare natural menstrual cycle groups with an oral contraceptive control group to determine if menstrual phase-specific training influences neuromuscular adaptations. Participants will: * Undergo 2 weekly resistance training sessions over 13 weeks with intensity adjustments based on menstrual phase * Complete periodic neuromuscular assessments across three menstrual phases: early follicular, late follicular, and mid-luteal before and after resistance training intervention