Clinical Research Directory

Effects of Pain Neuroscience Education on Pain, Kinesiophobia in Patients With Non Specific Low Back Pain

Chronic non-specific low back pain (NSLBP) is a highly prevalent musculoskeletal condition and a leading cause of disability worldwide. Psychological factors such as fear-avoidance beliefs and kinesiophobia significantly contribute to pain chronicity, reduced physical activity, and functional limitations. Pain Neuroscience Education (PNE) is a biopsychosocial educational approach designed to reconceptualize pain as a protective output of the nervous system rather than solely a marker of tissue damage. This randomized controlled trial aims to determine the effect of Pain Neuroscience Education combined with Core Stabilization Exercises on pain intensity and kinesiophobia in patients with chronic non-specific low back pain. A total of 62 participants aged 20-55 years with mechanical low back pain lasting ≥3 months will be randomly allocated into two groups: (1) Core Stabilization Exercises plus PNE (experimental group) and (2) Core Stabilization Exercises alone (control group). The intervention duration will be four weeks, with three sessions per week. Primary outcomes include pain intensity measured by the Numeric Pain Rating Scale (NPRS) and kinesiophobia measured using the Fear-Avoidance Beliefs Questionnaire (FABQ). Assessments will be conducted at baseline and post-intervention. The study hypothesizes that the addition of PNE will produce greater reductions in fear-avoidance beliefs and pain intensity compared to exercise therapy alone.

Effect of Knee Extensor Training on the Lumbar Spine

The goal of this clinical trial is to learn if knee extensor training with different protocols works to treat LBP in adults.. The main questions it aims to answer are: What are the comparative effects of open and closed kinetic chain knee extensor strengthening exercises versus lumbar stabilization exercises on lumbar curvature, postural control, and disability in individuals with non-specific low back pain? 1.4.2. How does open kinetic chain knee extensor strengthening affect pain, functional capacity, and lumbar spine stability compared to closed kinetic chain exercises in individuals with non-specific low back pain? 1.4.3 What is the effect of open kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability compared to conventional lumbar muscle exercises in individuals with non-specific low back pain? 1.4.4 What is the effect of closed kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability compared to conventional lumbar muscle exercises in individuals with non-specific low back pain? 1.4.5 What is the effect of open kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain? 1.4.6 What is the effect of close kinetic chain knee extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain? 1.4.7 What is the effect of conventional lumbar extensor strengthening on pain, functional capacity, and lumbar spine stability in individuals with non-specific low back pain Researchers will compare three different exercise protocols to a control group (will not receive exercise) to see if knee extensor training has an effect on problems associated with LBP. Participants will: * Exercise three times per week for 8 weeks * Be assessed before, 4 weeks after, and 8 weeks after intervention

AI-Enhanced Telerehabilitation Program Using Automated Video Analysis and Personalized Feedback on Pain, Disability, Mobility, Endurance, for Chronic Non-Specific Low Back Pain in College Students.

This study tests whether an artificial intelligence (AI)-enhanced telerehabilitation program can effectively treat chronic non-specific low back pain in college students. Low back pain affects 40-52% of university students due to prolonged sitting during lectures and study sessions, poor posture from laptop use, and lack of physical activity. While exercise therapy is the recommended treatment, many students cannot access traditional physiotherapy due to cost, scheduling conflicts, and location barriers. This randomized controlled trial compares three treatment approaches: (1) AI-enhanced telerehabilitation with automated video analysis and personalized feedback, (2) standard telerehabilitation with video instructions only, and (3) usual care. The AI system uses computer vision technology (Google MediaPipe Pose) to analyze exercise videos through a standard webcam or smartphone, automatically tracking joint movements, counting repetitions, and providing real-time feedback on exercise form. College students with chronic low back pain (lasting more than 3 months) will be randomly assigned to one of the three groups. The AI-enhanced group will receive personalized exercise programs delivered remotely, with the AI system monitoring their performance and physiotherapists providing guidance through video consultations. The study will measure changes in pain levels, disability, physical function, trunk muscle endurance, and quality of life over 8 weeks of treatment and 3 months of follow-up. Researchers will also evaluate how well participants stick to their exercise programs and how easy the technology is to use. This research aims to determine if AI technology can make remote physiotherapy more effective and accessible for college students, potentially transforming how young adults receive treatment for back pain and improving their long-term health outcomes.

Correlation Between the Flexibility of Hip Muscles, Pain and Disability in Chronic Nonspecific Low Back Pain

This study will be conducted to investigate the correlation between the flexibility of hip muscles; hip flexors (iliopsoas, rectus femoris), hip extensors (hamstring), hip internal rotators, hip external rotators, hip adductors and hip abductors with pain intensity and disability level among patients with chronic nonspecific low back pain