Clinical Research Directory

Clinical Comparison of Clear Aligners and Fixed Appliances in Dental Anterior Open Bite

Dental anterior open bite is a challenging orthodontic condition with a high risk of relapse in adults. This randomized controlled clinical trial aims to compare the effectiveness and post-treatment stability of in-house clear aligners versus fixed orthodontic appliances in treating adult patients aged 18-30 years with dental anterior open bite (0 to -4 mm). A total of 46 eligible participants will be randomly allocated into two equal groups (23 treated with clear aligners and 23 with fixed appliances). Treatment outcomes, vertical dentoalveolar changes, and skeletal changes will be evaluated using digital intraoral scans, virtual model superimposition, and lateral cephalometric analysis. Following active treatment, an 8-month retention phase (bonded lingual retainer combined with a vacuum-formed retainer) and an 8-month post-retention follow-up phase will be implemented to comprehensively evaluate treatment stability and relapse tendency over a total observation period of 16 months.

IOA Preventing Occlusal Changes With MAD Use

This study is evaluating two standard-of-care strategies used to prevent bite changes (occlusal changes) in patients treated with a Mandibular Advancement Device (MAD) for sleep-related breathing disorders such as obstructive sleep apnea (OSA). While MAD therapy is effective, it can lead to changes in how the teeth fit together, including the development of a posterior open bite. Participants in this study will be randomly assigned to one of two standard-of-care approaches: using an interocclusal aligner each morning after removing the MAD, or performing daily jaw exercises. Both methods aim to reduce the risk of occlusal changes. The study will follow participants over a 3-month period and includes dental evaluations, 3D oral scans, and short daily surveys. Findings from this research may help guide best practices for preserving occlusion during MAD therapy.

Investigate the Effectiveness of 3D-printed Shape Memory Aligners in the Treatment of Anterior Open Bite

The goal of this randomised clinical trial study is to investigate 3D-printed shape memory aligners in the treatment of anterior dental open bite adult patients. The main questions it aims to answer are: 1. Do 3D-direct-printed shape memory aligners demonstrate potentiality in the management of AOB? 2. What is the effect of 3D-direct printed shape memory aligners on molar intrusion? 3. Can the 3D-direct printed shape memory aligners extrude anterior teeth without the use of attachments? 4. Do 3D-direct printed shape memory aligners generate greater/higher stress distribution and initial teeth displacement compared to conventional clear aligners? Researchers will compare three groups: Group I: Patients treated with conventional clear aligners with attachments; Group II: Patients treated with 3D direct-printed shape-memory aligner without attachment; Group III: Patients treated with 3D direct-printed shape memory clear aligners with attachments and see its effect on anterior open bite treatment. Participants will wear a clear aligner for about 6-8 months. Then

Stability of Orthodontic Treatment of Anterior Open-bite

The study aims to explore how an open bite malocclusion affects daily life of an individual, is its orthodontic treatment effective, and what kind of burden of care the treatment has caused.

Anterior Open Bite Closure by Clear Aligners Versus Fixed Appliances in Adult Patients With Skeletal Open Bite: A Randomized Clinical Trial.

Here's a 1,000-word (quarter-length) concise version of your research brief, preserving the key structure and essential details: Brief Summary: Comparative Management of Skeletal Anterior Open Bite Using Mini-Screw Supported Intrusion with Clear Aligners Versus Fixed Appliances PICO elements Population: Adults (17-25 years) with uncompensated skeletal anterior open bite. Intervention: TAD-supported intrusion with clear aligners. Comparison: TAD-supported intrusion with fixed appliances. Outcomes: Primary: Anterior open bite closure. Secondary: Molar intrusion, mandibular autorotation, incisor movement and quality of life.

Myofunctional Therapy in Open Bite - RCT

The goal of this clinical trial is to learn if myofunctional therapy in 6-10-year-old children with infant type of swallowing and open bite is effective. Primary hypothesis: myofunctional therapy results in correction of open bite Researchers will compare a group in which myofunctional therapy is performed for 6 months to a group in which myoufunctional therapy will be delayed by 1 year. Participants will exercise according to a pre-established regimen and schedule