Clinical Research Directory

PeerScreen Trial - Reducing Screen Media Use in Peer-groups of Young People

The purpose of the PeerScreen trial is to investigate whether reducing screen media use affects mental health, social interaction, sleep, physical activity, heart rate variability, and behavioral patterns in young people aged 13 to 24 years. The primary question the trial aims to answer is: Does reducing screen media use over a 4-week period improve mental health among young people? Researchers will compare a screen media reduction intervention with a control condition in which participants continue their usual screen media use to determine whether reducing screen media use leads to improvements in mental health. Participants will: * be allocated to either a 4-week screen media reduction intervention or a control condition * complete a study protocol including questionnaire-based assessments, daily self-reports, and objective monitoring of screen media use, sleep, physical activity, heart rate variability, social interactions, and geolocation

StandUPTV Habits: Feasibility Trial for Maintaining Reductions in Sedentary Screen Time

Our goal in this study is to further refine StandUPTV, an application designed to reduce SST in adults in our first study (ASU IRB # STUDY00012109), for the StandUPTV Habits program. This program aims to establish a non-sedentary habit triggered by an alert from the StandUPTV application after participants engage in approximately 30 minutes of SST in the evening.

Guided Physical Activity Counseling: A Pilot Study

This 1-arm pilot study will test the feasibility of recruitment and use of the Physical Activity Counseling Tool (PACT) in 40 UC San Diego Health patients.

On Track for Wellness (OTW) Stepped Wedge Cluster Randomized Trial

This study will evaluate a program called On Track for Wellness (OTW) which is being adopted by the Illinois Department of Human Services' Division of Behavioral Health \& Recovery (DBHR) for use in all state-funded early psychosis programs in Illinois. OTW combines use of Fitbit activity trackers with health education, goal setting to promote health activation, and ongoing support for maintaining healthy lifestyles. Successful completion of this research will gauge the effectiveness of this program in improving sleep hygiene and increasing physical activity among people recently diagnosed with schizophrenia or other psychotic disorders.

Prediction of Chronic Disease Using Explainable Hybrid Machine Learning

In this study, a 28-item questionnaire developed by the researchers (Aysun Atacan and Gülşen Taşkın) will be used as the data collection tool. Since the intellectual property rights and developer identity belong to the researchers, there are no copyright or usage restrictions. Containing both qualitative and quantitative evaluation questions, the questionnaire consists of 5 main sections: personal information, daily life assessment, walking level assessment, household chores assessment, and work/workplace assessment. Eight of the questions cover sociodemographic information, while 20 focus on determining and evaluating physical activity levels in daily life, walking, home, work, and transportation. Participants are asked to answer the questions by considering their lifestyle over the past month. Based on these data-recorded according to how many days per week and how many minutes per day the activities are performed-calculations will be made by multiplying the MET value, frequency (days/week), and duration (minutes/day) to obtain the "MET-min/week" score. Participants will be categorized into three groups based on their total weekly MET expenditures: \<600 MET-min/week as inactive, 600-3000 MET-min/week as minimally active, and \>3000 MET-min/week as health-enhancing physically active (sufficiently active); and into groups based on their average daily step counts: \<5000 as sedentary/inactive, 5001-7499 as low active, 7500-9999 as somewhat active, 10000-12499 as active, and \>12500 as highly active. Chronic disease risk predictions will then be evaluated via machine learning based on these physical activity levels and step counts. The primary aim of this research is to quantitatively demonstrate the impact of physical activity levels and lifestyle habits on chronic disease risk factors using machine learning (ML) methods. The models to be developed aim not only for high predictive performance but also for the clinical interpretation of which physical activity parameters are more decisive on disease risk, utilizing explainable artificial intelligence methods such as SHapley Additive exPlanations (SHAP). Consequently, the goal is to establish a decision support mechanism for the early detection of individuals at risk and to place personalized exercise prescriptions on a scientific foundation.

Multiple Sclerosis Severity and Caregiver Health Outcomes

This cross-sectional observational study aims to investigate the associations between multiple sclerosis (MS) severity and caregivers' sleep quality, physical activity, body awareness, perceived stress, and caregiver burden. A total of 68 caregivers of patients with MS will be recruited from Başkent University Hospital. MS severity will be assessed using the Expanded Disability Status Scale (EDSS), while caregiver health outcomes will be evaluated using validated questionnaires. The findings are expected to provide insight into the multidimensional impact of MS severity on caregiver health and well-being.

Strong Teens for Healthy Schools Change Club: A Civic Engagement Approach to Improving Physical Activity and Healthy Eating Environments

Strong Teens for Healthy Schools (STHS) is a school-based, civic engagement program that empowers middle school students to improve their physical activity and healthy eating behaviors, improve their cardiovascular disease outcomes, and create positive change in their school health environments.

A Multi-level Mother-daughter Physical Activity Intervention for Pre- Adolescent Latinas

The goal of this Cluster Randomized Control Trial (RCT) is to learn if the mother-daughter intervention titled "Conmigo" can increase Latina preadolescents' physical activity (PA). The main objectives of the study are: * To test the effectiveness of Conmigo on daughters' Moderate-to-Vigorous level PA (MVPA) over time * To evaluate individual (e.g. mothers' MVPA) and family level (e.g. mother-daughter communication) mechanisms of change and their bidirectional effects Researchers will compare the 10-week physical activity promotion intervention to a 10-week parallel intervention with emphasis on another health behavior (dietary intake) to see if there are differences in MVPA levels. We will enroll 216 Latina mother-daughter pairs at 18 elementary schools; each school will randomly receive the PA intervention or the control group program. Mothers and daughters will attend 10 weekly sessions (2 hours each) at their elementary school, led by YMCA staff. Informed by social cognitive theory and family systems theory, the PA intervention sessions target family-level correlates of physical activity such as PA promotion parenting strategies (monitoring, role-modeling, etc.) and mother-daughter communication. Participants in the intervention group engage in weekly PA during sessions, discuss different topics each week, and set goals and receive PA homework during the week. The investigators hypothesize that daughters participating in Conmigo will have higher minutes of device-assessed MVPA at M2 (post program), M3 (6 months post program), and M4 (12-months post program) compared to girls in the control condition.

Effectiveness of an Intervention Combining Adapted Physical Activity and Therapeutic Education in Patients With Chronic Symptoms Attributed to Lyme Borreliosis.

Lyme borreliosis, commonly known as Lyme disease, has been clinically described for more than a century, but has been officially recognized for 40 years, with the detection of the Borrelia bacterium by W. Burgdorfer, in ticks of the Ixodes ricinus complex, identified a few years before.

Cities for Better Health Childhood Obesity Prevention Initiative in JAPAN

The goal of this interventional study is to prevent childhood obesity in children aged 6-12 years in Chiba City, Japan. The main questions it aims to answer are: * Does the multi-component intervention for environments around children reduce the BMI z-score of children aged 6-12 years after one and two years? * Does the multi-component intervention for environments around children improve the health-related quality of life (assessed by KIDSCREEN-10) of children aged 6-12 years after one and two years? Researchers will compare school clusters receiving the intervention to control clusters to see if the intervention package promotes healthy eating, increases physical activity, improves health-related quality of life, and reduces obesity prevalence. Participants will: * Attend elementary schools within participating clusters (either the intervention or control group). * Have baseline data collected, with follow-up assessments after one year and two years. * Potentially participate in school-based programs (nutrition education, physical activity promotion) and community-based initiatives (park activation, supermarkets) if in an intervention cluster. * Have their physical activity and dietary behavior assessed through self-report questionnaires.

Measuring Outcomes With Validated Exercise

Physical activity and its intensity level is a critical determinant of health. Digital Health Technologies, such as wearable accelerometers (wrist-worn watch-like devices), can provide researchers and clinicians with objective measures of activity intensity, duration, and effect on an individual's physiology which can provide important insight into overall health. The purpose of this observational study is to assess how well wrist-worn devices can measure the intensity of movement and exercise. This study is designed to rigorously validate existing activity classification algorithms using synchronized multi-sensor data and indirect calorimetry during structured, semi-structured, and free-living tasks.

Sleep and Physical Activity in Patient and Caregiver Dyads Following Allogeneic Hematopoietic Cell Transplantation

To understand the changes in health-related quality of life of patients and caregivers after allogeneic hematopoietic cell transplantation.

Impact of Adolescence Body Image on Body Functionality and Physical Activity

This cross-sectional study will investigate how Egyptian adolescents aged 14-17 years perceive their bodies and how these perceptions are related to body functionality and physical activity. The study will examine different patterns of body image concerns, including high, moderate, and low concern, and explore whether these patterns are associated with how adolescents appreciate what their bodies can do and how physically active they are. Participants will complete questionnaires assessing body shape concerns, body appreciation and functionality, and physical activity. The study aims to improve understanding of the relationship between body image, body functionality, and physical activity during adolescence and may provide useful information for healthcare professionals, particularly physical therapists, when developing strategies to promote physical activity and overall well-being among adolescents.

Physical Activity in Lawyers: Factors Affecting Musculoskeletal Pain

This study aims to determine the prevalence and distribution of musculoskeletal pain among lawyers registered with the Isparta Bar Association, specifically in relation to their varying levels of physical activity. The data obtained will help establish the relationships between physical activity levels, occupational factors, stress, and job satisfaction, thereby providing a foundation for developing personalized and preventive physiotherapy approaches for this specific population. Furthermore, the study will serve as a guiding resource for the ergonomic improvement of lawyers' working conditions and the formulation of occupational health policies. H1: There is a statistically significant relationship between lawyers' physical activity levels and the frequency, distribution, and severity of musculoskeletal pain in various anatomical regions of the body. H2: Physical activity level, perceived stress, occupational burnout, and job satisfaction levels are significant predictors of musculoskeletal pain among lawyers. H3: There is a statistically significant difference between lawyers' sociodemographic and professional characteristics (duration of employment, daily time spent at a desk and using a computer, etc.) and their perceived stress and job satisfaction scores. H4: Musculoskeletal complaints and functional limitations are significantly higher among lawyers experiencing high levels of perceived stress and occupational burnout compared to the group reporting low stress and burnout.

Welcome to WellnessRX: Steps Toward a Healthier Life!

Wellness Rx is a 6 class prescription for a healthier lifestyle developed for people in Lake County at all levels of health including those struggling with chronic disease. The classes are running across the community at all times. It is designed for patients that could benefit from healthy diet, exercise, and other healthy lifestyle modifications. For those participants attending the classes, they have the option of engaging in this evaluation. For those that do, participants will answer questions about their current lifestyle, their and their previous history. They will register attendance at each class and answer questions about their perception of the class. Then at 45 days and 90 days the participants will revisit the same baseline lifestyle questionnaires. As participants attend classes, and complete questionnaires, they'll unlock grocery credits from online food store ThriveMarket, a basket of fresh produce from the local farmers market and local fitness classes to help you towards your goals. The use of these credits will be tracked through the 90-day point.

REmote Physical ACtivity Intervention for High Blood Pressure Postpartum

The purpose of this intervention is to help new mothers who had elevated blood pressure during pregnancy become more physically active after birth. The investigators will connect data from FitBits to the electronic health record. Women will then get weekly messages with feedback and goals to help them stay active. The investigators will test if the intervention improves step counts and blood pressure after pregnancy. The investigators will also test if the intervention is feasible and enjoyed by postpartum women.

An Online Intuitive Eating Program for Pregnant Women With Obesity to Support Well-Being

The goal of this feasibility randomized controlled trial is to assess the feasibility, acceptability, and demand, as well as preliminary effects of an evidence-based Intuitive Eating (IE) intervention among pregnant women who have obesity. The main research questions are: RQ1: What is the feasibility (acceptability and demand) of implementing an Intuitive Eating Intervention among pregnant and postpartum women? RQ2: How does participation in the Pregnancy Intuitive Eating Intervention (PIE-I) impact key maternal health outcomes (i.e., gestational weight gain, intuitive eating behaviors, dietary quality, body image, and mental health) compared to a wait-list control? Researchers will compare the Pregnancy Intuitive Eating Intervention (PIE-I) intervention group with the wait-list control to see what impact the PIE-I has on maternal well-being. Participants randomized to the intervention group will complete the 8 week asynchronous IE intervention and have an opportunity to interview at the end of the study.

Impact of a Physical Activity Intervention on Sleep Quality, Mental and Physical Well-Being in Health Sciences Students

This randomized controlled trial aims to compare the effects of a regular weekly physical activity program versus a "Weekend Warrior" activity pattern on sleep quality, physical well-being, and mental well-being in sedentary university students. Participants will be randomly assigned to one of the intervention groups or to a control group and assessed at baseline and after the intervention.

The prEgnanCy and eArly Childhood nutrItion triaL (ECAIL)

The purpose of this study is to conduct a randomized controlled trial among 800 socially disadvantaged pregnant women and their families to test the effectiveness of a multi-component home visitation nutrition program, compared to usual care, in promoting healthy feeding practices, lifestyle behaviors and growth in young children.

Primary Care Referrals to a Remotely Delivered Physical Activity Intervention for Latina Teens: Chicas Fuertes 2

This study will test a physical activity intervention for Latina teenagers. Investigators will recruit 200 Latina adolescents who are currently under-active to participate in this 12-month study. Participants will be referred to the study by their primary care provider. Half of the participants will be randomly selected for the Intervention group, and will receive an individual counseling session and access to a personalized website. These participants will also receive a Fitbit activity tracker to help with goal setting and monitoring, plus weekly text messages and access to the study Instagram account to remind participants to be physically active. Those assigned to the control group will receive the Fitbit activity tracker.

Mobile-Based Intervention to Promote Physical Activity Among the Elderly

This study aims to explore the feasibility and preliminary effectiveness of a mobile phone-based intervention among elderly individuals with chronic diseases.

Intervention to Increase Physical Activity and Wellbeing Among Staff and Residents in Assisted Living Facilities

The purpose of the study is to test a program that aims to help staff increase wellness behaviors and test the impact of this program on staff and work outcomes. We will also assess the impact of the program on residents' physical activity and function.

Evaluation of Choose to Move Replacement Ready (CTM-RR)

Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada. Recently, the investigators adapted CTM for the \>14000 people in BC who are on surgical waitlists for total knee replacement or total hip replacement (TKR/THR) for osteoarthritis (OA). The primary goals of this observational study are to describe how the adapted program, Choose to Move Replacement Ready (CTM-RR), is implemented in BC and determine if the adapted program improves health outcomes in people with hip and/or knee osteoarthritis who are on surgical waitlists for TKR/THR. The investigators will also evaluate whether any health benefits achieved by CTM-RR participants are maintained three months after they finish the program and also during the remaining time that they wait for their TKR/THR surgery. The investigators will work with referral partners from hospitals and orthopaedic clinics in BC to recruit participants into CTM-RR. Participants who enrol in CTM-RR will answer online survey questions about the program and about their physical activity, mobility, pain, function, quality of life, willingness to undergo surgery, overall perception of their joint condition, psychosocial health, self-efficacy, social isolation, loneliness, and sedentary time. CTM-RR activity coaches will also answer online survey questions about the program. CTM-RR participants, activity coaches, and referral partners will also participate in interviews about the program.

Using Tailored mHealth Strategies to Promote Weight Management Among Adolescent and Young Adult Cancer Survivors

The AYA WELL study is a 2-arm randomized clinical trial to test the efficacy of a theory-based, mHealth weight management intervention adapted specifically for adolescent and young adult cancer survivors compared to a self-guided arm. Participants, diagnosed with cancer between ages 15-39, currently age 18-39, post-treatment at least 6 months, and who have overweight or obesity will be randomized to receive either: 1) a comprehensive mHealth weight management program (intervention) or 2) digital tools + health education + peer support (self-guided) over 12 months. Outcomes will be assessed at 3, 6, and 12 months.