Clinical Research Directory

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Respiratory Distress Syndrome (& [Hyaline Membrane Disease])

Tundra lists 1 Respiratory Distress Syndrome (& [Hyaline Membrane Disease]) clinical trial. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.

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NOT YET RECRUITING

NCT07377955

Combined Oscillation-Volume guarantEe Study

Respiratory Distress Syndrome (RDS) remains the most common respiratory complication in the early postnatal period among preterm infants born before 32 weeks' gestational age. For this population, implementing lung-protective ventilation strategies is essential to shorten the duration of intubation, reduce the incidence and severity of bronchopulmonary dysplasia (BPD), lower mortality, and improve overall outcomes. HFOV-VG was first reported in 2015 to be safely applied in neonates. The fundamental principle lies in its ability to stabilize the tidal volume of high-frequency ventilation (VThf), thereby reducing sheer stress from amplitude fluctuations, while simultaneously permitting lower VThf settings to minimize volutrauma. This study aims to evaluate whether HFOV+VG is superior to HFOV in reducing the composite outcome of grade 2-3 BPD or death at 36 weeks' post-menstrual age (PMA).

Gender: All

Updated: 2026-01-30

Respiratory Distress Syndrome (& [Hyaline Membrane Disease])

Bronchopulmonary Dysplasia (BPD)