Clinical Research Directory

What Influence Re-participation in the Danish Colorectal Screening Program.

This prospective observational study investigates how participants experience screening colonoscopy within the Danish colorectal cancer screening program and how these experiences relate to clinical findings, procedural factors, and future participation in screening. The study aims to evaluate patient-reported experiences such as pain, discomfort, preparation burden, emotional responses, and perceptions of healthcare staff, as well as staff-assessed pain during the procedure. These experiences will be examined in relation to colonoscopy findings, including polyp detection, histology, risk stratification, and colorectal cancer detection. In addition, procedure-specific variables such as insertion time, bowel preparation quality, completeness of colonoscopy, medication use, and adenoma detection rate will be analyzed in relation to patient experience. A key focus is whether the experience of screening colonoscopy influences subsequent participation in the colorectal cancer screening program, particularly among individuals classified as low risk and re-invited for screening after two years. Registry-based follow-up will be used to assess re-participation. Data are collected prospectively from two sources: (1) real-time procedure data entered by healthcare staff during colonoscopy and (2) patient-reported outcomes collected via a questionnaire completed shortly after the procedure. Additional outcome data are obtained from electronic medical records and national health and screening registries. The study has no single predefined hypothesis. Instead, it serves as a data-generating platform designed to address both predefined and future research questions related to screening colonoscopy experiences, quality indicators, and screening adherence.

Could Computerized Tomography be an Alternative to Colonoscopies for Screening for Colorectal Cancer?

The aim of this observational study is to investigate whether computed tomography can be used as an alternative to colonoscopy in colon cancer screening. The main question the study aims to answer is: Can colon cancer screening be performed as effectively with computed tomography as with colonoscopy? Participants in the colon cancer screening group will be divided into two groups: those who underwent colonoscopy and those who underwent computed tomography. The screening effectiveness of the two methods will be compared.

Longterm Effectiveness of Artificial Intelligence-assisted Colonoscopy on Adenoma Recurrence

We hypothesize that AI-assisted colonoscopy can reduce post-colonoscopy neoplasia incidence after 3 years, over standard colonoscopy. Moreover, this protective effect may allow surveillance intervals to be lengthened, by modifying long-term outcome of high-risk subgroup.