Clinical Research Directory

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits of tegavivint in treating patients with solid tumors that has come back (recurrent) or does not respond to treatment (refractory). Tegavivint interferes with the binding of beta-catenin to TBL1, which may help stop the growth of tumor cells by blocking the signals passed from one molecule to another inside a cell that tell a cell to grow.

Multicentric Database for Solid Pseudopapillary Neoplasm of the Pancreas

To establish and maintain a reliable multicenter real-world database for pancreatic SPN, providing high-quality data and evidence-based support for clinical/translational research.

Validation of Joint-AI in Diagnosing Pancreatic Solid Lesions

This clinical trial aims to learn if a multimodal artificial intelligence (AI) model can enhance the diagnosis of pancreatic solid lesions. The main questions it aims to answer are: 1. Does the AI model enhance the diagnostic performance of endoscopists in diagnosing pancreatic solid lesions? 2. Does the addition of interpretability analysis further improve the diagnostic performance of the assisted endoscopists? Researchers will compare the diagnostic performance of endoscopists with or without the assistance of the AI model. Participants will: 1. Their clinical data will be prospectively collected. 2. They will be randomized to the AI-assist group and the conventional diagnosis group.