Clinical Research Directory

Ultra-brief Psychological Treatments for Emotional Symptoms and Disorders

The main objective of this randomized clinical trial is to study if various modalities of brief (eight sessions) and ultra-brief (four sessions) transdiagnostic cognitive-behavioral treatment work for decrease emotional symptoms and disorders, as well as to find out which variables of cognition and of the intervention process itself are involved in the therapeutic improvement. The investigators will compare the interventions of four groups: brief group treatment (1), ultra-brief group treatment (2), ultra-brief individual treatment (3) with the ultra-brief relaxation (control) group. The main questions the study aims to answer are: * Will the brief and ultra-brief treatment formats works better than the relaxation-based control group? * Will results obtained between the brief group therapy group and the ultra-brief group therapy group be similar? * Will the individual ultra brief therapy be more effective than the two group therapies because of common factors, such as the therapeutic alliance? * Will group therapies be more beneficial for cost and in terms of capability to reduce emocional symptoms than individual therapy? Participants will be randomly assigned to each of the groups and will receive the corresponding treatment, with different number of sessions. They will answer a series of questionnaires at the beginning and at the end of the intervention, as well as 3 months and 6 months after the end of the treatment.

Internet-based Treatment for Patients Suffering From Severe Functional Somatic Disorders

The aim of this multi-center, two-armed, randomized controlled trial is to assess the effect of a novel internet-based therapist-assisted treatment program "One step at a time" designed for the treatment of patients with moderate to severe functional somatic disorder (FSD). The trial will enroll 166 patients with FSD who will be randomized (1:1) to either the experimental condition (14 weeks' treatment with "One step at a time") or the active control condition ("GetStarted"), which is a non-guided internet-based treatment program for patients with FSD. The trial will include patients aged 18-60 years with an established single/oligo-organ or multi-organ FSD diagnosis, with a duration of minimum 6 months. The primary outcome measures will be based on self-reported physical health (SF-36 PPH) and treatment satisfaction (CGI-I). The trial will be considered effective if a higher proportion of patients in the experimental condition report a clinically significant outcome compared with patients in the active control condition at the 3-month follow-up after treatment.

Mindfulness Meditation: Alleviating Symptoms and Inflammation in Nurses

Background: Nurses have experienced several stressors, the most important of which are increased workloads, long shifts, patients' negative results, some patients not responding to treatment, death at high rates, late detection of disease cases, lack of social support system, and limited typical coping. Aim: The purpose of this study is to assess the effectiveness of mindfulness meditation for clinical nurses to improve perceived stress and somatic symptoms and pro-inflammatory factors. Among Jordanian clinical nurses. Methodology: The study will be conducted using a post-test randomized controlled experimental design. The study data will be collected using a self-report questionnaire and blood sampling from 102 nurses in in King Abdullah hospitals at baseline and at the end of intervention. Data were analyzed using the Statistical Package for Social Science (SPSS), Version 26.

Perinatal Mental Health Study (PMHS) India

The purpose of this observational study is to improve understanding of mental disorders among perinatal women in India.