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Tundra lists 2 Spinal Induced Hypotension in Cesarean Delivery clinical trials. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.
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NCT07324512
Minimum Effective Volume of Crystalloid Co-Loading to Prevent Spinal Anesthesia-Induced Hypotension in Cesarean Section
The goal of this clinical trial is to find the minimum effective volume of IV crystalloid that should be given with phenylephrine to prevent hypotension caused by spinal anesthesia in healthy, term pregnant adults having elective cesarean delivery. The main questions are: What is the minimum effective volume (MEV90, mL/kg) of crystalloid co-loading that prevents spinal-anesthesia-induced hypotension in ≥90% of participants? What maternal side effects and newborn outcomes occur with this strategy (e.g., nausea/vomiting, need for extra vasopressors, total fluids/blood loss, Apgar scores, and umbilical cord blood gases)? There is no separate comparison group; this is a single-arm, adaptive dose-finding study. Participants will: Receive a predefined volume of IV crystalloid over \~10 minutes during spinal anesthesia while phenylephrine is infused. Have blood pressure and symptoms monitored; receive rescue treatment if needed. Allow the next participant's fluid volume to be adjusted based on whether hypotension occurred (biased-coin design). Be followed through postoperative day 2 for maternal and newborn outcomes.
Gender: FEMALE
Ages: 19 Years - Any
Updated: 2026-01-07
NCT06885593
Femoral Vein Collapsibility Index and Post-Spinal Hypotension in Pregnant Women: Impact of Position
This study aims to improve the safety of spinal anesthesia for pregnant patients undergoing elective cesarean delivery. Specifically, the investigators are investigating whether ultrasound measurements of a vein in the groin (the right common femoral vein, or RCFV) can help predict the risk of low blood pressure (hypotension) after spinal anesthesia. The main question it aims to answer is: Can femoral vena cava collapsibility index predict post-spinal hypotension in pregnant women in left lateral tilt position? Before receiving spinal anesthesia, participants will undergo a brief and painless ultrasound examination of the RCFV in the groin area while lying in a specific position."
Gender: FEMALE
Ages: 18 Years - Any
Updated: 2025-03-20