Clinical Research Directory

Effectiveness of Enzyme Spray Intervention on Thirst Relief in Patients With Endotracheal Intubation.

This study addresses the high prevalence (66%-70%) of thirst among intensive care unit (ICU) patients with endotracheal intubation, a symptom associated with oral mucosal dryness, nil per os (NPO) status, oxygen therapy, and medication effects. Unrelieved thirst may contribute to anxiety, delirium, and unplanned extubation. Current clinical practices, such as cold water or saline sprays, generally provide only short-term relief, while direct oral water administration may increase the risk of choking or aspiration. Enzyme-based saliva substitutes, which mimic components of natural saliva and may help maintain oral moisture, show potential benefits; however, evidence in ICU populations remains limited. This randomized controlled trial with blinded outcome assessment was conducted in a surgical ICU at a medical center in southern Taiwan. Eligible participants were adult patients (≥18 years) with endotracheal intubation expected to exceed 24 hours, a baseline thirst intensity score (NRS-I) ≥3, and the ability to communicate. A total of 76 participants were randomly assigned in a 1:1 ratio to either the experimental group (enzyme-based oral spray) or the control group (distilled water spray), using sequentially numbered, opaque, sealed envelopes (SNOSE) to ensure allocation concealment. The intervention was administered following routine oral care within a standardized time window (13:00-15:00). Both solutions were prepared in identical opaque spray bottles using standardized procedures. Participants were not informed of their group allocation; however, because sensory characteristics after oral administration could differ between the two solutions, complete participant blinding could not be assured. Outcome assessments were performed by trained research nurses who were blinded to group allocation. The protocol included 12 sprays per session (approximately 1.56 mL), delivered to four standardized intraoral sites, with outcomes monitored over a 4-hour period. Thirst intensity was measured using the Numerical Rating Scale-Intensity (NRS-I), and thirst distress was measured using the Numerical Rating Scale-Distress (NRS-D). Both outcomes were assessed at baseline (T0) and at 30, 60, 120, and 240 minutes post-intervention (T1-T4) by blinded outcome assessors to evaluate changes in thirst symptoms and the persistence of symptom relief over time. No biological specimens were collected; data were obtained from self-reported measures and electronic medical records, with strict de-identification and secure storage procedures. This study was considered minimal risk. Predefined safety criteria required immediate discontinuation of the intervention if adverse events such as discomfort, choking, respiratory deterioration, or other clinically significant events occurred. Data were analyzed using generalized estimating equations (GEE) to evaluate group, time, and group-by-time interaction effects while accounting for correlations among repeated measurements. The study aimed to provide evidence to inform thirst management, enhance patient comfort, and support clinically feasible nursing care for patients with endotracheal intubation in critical care settings.

Effects of Aromatic Solution Applied After Surgery

Today, surgical applications are used to solve many health problems. In order for the surgical intervention to take place, anesthesia applications are often required. Complications such as sore throat, thirst and nausea and vomiting may occur as a result of trauma, local irritation and inflammation of the airway mucosa during anesthesia and tracheal intubation. These complications are in the postoperative period; It may cause delayed oral fluid intake, prolonged dehydration, oral odour, and increased risk of aspiration, hematoma and wound dehiscence due to retching and vomiting, all of which may lead to delayed discharge and increased cost. Aromatherapy, one of the non-pharmacological applications, is frequently applied in reducing postoperative complications and its effectiveness is stated. In this study, the aromatic solution applied after the surgery; It was planned to examine the effect on sore throat, thirst, nausea-vomiting. In addition, the multimodal synergistic effect of lavender oil and ginger oil used in the aromatic solution to be prepared will be utilized. As a result of this study, the effectiveness of the aromatic solution application to be applied to the patients in the postoperative period and the benefits and benefits of the patient's recovery process will be determined. Thus, effective application can be made for the entire postoperative period. It is thought that this study to be conducted will be a guide for future studies on the patient group.

Comparison of Four Different Methods Used To Relieve Postoperarive Thirst-Related Discomforts

This study was conducted to compare four different methods applied to relieve thirst-related discomfort after surgery. The study is a prospective, randomized controlled, experimental research conducted at Afyonkarahisar Health Sciences University Health Practice and Research Center General Surgery Clinic. The study took place between November 2022 and April 2023. 150 patients divided into control and intervention groups were included. The study aimed to investigate the effects of four different methods of quenching thirst after surgery on patient outcomes. Data collection tools include Patient Introduction and Follow-up Form, Numerical Verbal Scale (0 10) to measure thirst intensity, Safe Protocol for the Management of Early Post-Operative Thirst, Surgical Period Thirst-Related Discomfort Scale (CDSBRÖ), Perianesthesia Comfort Scale (PCS) and satisfaction level. Numerical Verbal Scale (0-10) was used to determine. The focus of the data study between groups was on postoperative thirst management, patient comfort, and satisfaction with different interventions. The significance level of 0.05 was taken as the criterion in interpreting the results.

Safe Brain Initiative, Operationalizing Precision Anaesthesia

Perioperatively, patients experience an unnecessarily high level of side effects associated with their treatment. These side effects include nausea, severe pain, anxiety, and stress. Moreover, many patients develop postoperative delirium (POD) and neurocognitive dysfunctions, often resulting in long-term cognitive impairment, decreased quality of life, and increased mortality. However, physicians, nurses and their institutions do not receive structured feedback regarding these aspects of each patient's well-being. They may therefore be unable to engage in the essential cause-and-effect learning necessary to evaluate and consecutively reduce such side effects. Effective guidelines conform prevention is the proven key to shielding our patients from adverse Outcomes. The Safe Brain Initiative's high-quality routine data-for-action is a sword and accelerator for moving towards patient-centred, precision care. Thus, establishing a foundation for value-based and patient-centred healthcare development. However, a turnkey real-world solution is challenging to develop and implement and requires substantial resources. As a result, such solutions are usually beyond the scope of a single institution. The SBI platform provides high-quality, real-world data to bridge this gap. It allows monitoring and in-depth analysis of cause and effect in the day-to-day routine of individuals, departments, and institutions. The SBI's approach is continuously improved and updated. An organization called the SBI Global Society oversees the quality and precision of science through experts in the field. At SBI Hospitals and Flagship centres, Masterclasses are conducted and can be attended alongside clinical immersions. SBI Solutions manages, develops, and provides technical and service support for the Safe Brain Initiative. Its service guarantees the professional and GDPR conform management of data handling and storage as well as the user-friendly functionality of the SBI-Dashboard solutions.

The Effect of Intervention About Dry Mouth and Thirst in Patients With Endotracheal Tube

This is an experimental study aimed at exploring the effectiveness of using 4°C frozen gauze with normal saline for relieving dry mouth and thirst in patients with endotracheal tubes.