Clinical Research Directory

Comparison Between Continuous and Pulse Itraconazole in Tinea Capitis in Children

A study to compare the efficacy of daily therapy versus pulse therapy of oral itraconazole in the treatment of tinea capitis in children based on clinical, mycological and dermoscopic evaluation.

Population Pharmacokinetics of Terbinafine in Children With Tinea Capitis

The goal of this observational study is to characterize the population pharmacokinetics (PPK) of terbinafine in pediatric patients with tinea capitis, evaluate its efficacy and safety, and identify covariates affecting drug disposition in Chinese children aged 2-18 years diagnosed with tinea capitis and treated with oral terbinafine. The main questions it aims to answer are: What are the terbinafine pharmacokinetic parameters (e.g., AUC, CL, V) in children with tinea capitis, and how do they differ from adult values? Which covariates (e.g., age, body weight, CYP enzyme activity, renal function) significantly influence inter-individual variability in terbinafine PK parameters? What is the clinical efficacy (based on TSSS reduction and mycological cure rate) and safety profile of terbinafine in this pediatric population? Participants will: Undergo oral terbinafine treatment according to weight-based dosing (62.5-250 mg daily). Concentration determination is carried out using the opportunistic sampling method. Complete clinical assessments (TSSS scoring) and mycological examinations (microscopy/culture) at baseline and follow-up visits. Undergo routine laboratory tests (liver/kidney function, hematology) to monitor safety.

Trichoscopic Predictors of Treatment Response in Tinea Capitis: A Prospective Study

Brief Summary (Plain Language Version) The goal of this observational study is to learn how well changes seen under a special microscope called a trichoscope (used to look at hair and scalp) match the success of treatment in children and adolescents with a scalp fungal infection called tinea capitis. The main questions it aims to answer are: Do changes in trichoscopic findings show when the fungal infection is cured? Does having more severe trichoscopic findings at the start mean that treatment will take longer or be less successful? Do different fungus types respond differently to the same treatment? Participants will: Be between the ages of 0 and 18 with confirmed tinea capitis based on lab tests (microscopy and/or culture) Receive an oral antifungal medicine called terbinafine for 4 weeks (dosing based on weight) Attend regular checkups every 4 weeks until both scalp appearance and lab tests show the infection is gone At each visit, participants will: Have their scalp examined using a trichoscope Provide scalp samples for fungal testing Be assessed for symptoms like itching, redness, and scaling The study will also look at how fast different signs on the scalp go away, and which of these signs are best at predicting whether the fungus is still present.

Efficacy and Safety of Topical Amphotericin B Solution in Treatment of Resistant Tinea Capitis in Children 16 Years Old or Less we Follow up Cases Weekly up to 8 Weeks and Notice Improvement of Itching ,Scaling, and Hair Regrowth Then Fungal Culture Done to See if the Solution Working

The goal of this clinical trial is to learn if topical amphotericin b solution works to treat resistant cases of tinea capitis in children. It will also learn about the safety of drug. The main questions it aims to answer are: Does amphotericin b solution effective in cases not cured by systemic antifungal tab? Participants will: use topical amphotericin b solution every day for8 weeks Visit the clinic once every 1 week for follow up then follow up after 1 month and fungal culture will be done to test if the treatment working