Clinical Research Directory

Additional Palatal Force in Maxillary Canine Distalization

In orthodontic treatment involving extraction of the maxillary first premolars, the canine is distalized into the extraction space using sliding mechanics. Because the retraction force is applied at bracket level and therefore at a distance from the centre of resistance of the tooth, the canine tends to rotate distopalatally and to tip in the sagittal plane instead of translating bodily. These side effects lengthen treatment and increase the load on the posterior anchorage teeth. Power arms are used to bring the line of action of the force closer to the centre of resistance. In addition, because the centre of resistance of the maxillary canine lies palatal to the mid-buccolingual axis of the crown, a force applied from the palatal surface generates a rotational moment opposite in direction to that produced by a buccal force. This trial tested whether dividing a constant total distalizing force between the buccal and the palatal surfaces of the canine, so that the two rotational moments oppose one another, produces a more bodily canine movement than applying the whole force from the buccal side alone. The trial used a split-mouth design: in each participant one maxillary quadrant received the whole force from the buccal side and the contralateral quadrant received half the force buccally and half palatally, with the total force identical on both sides. Canine displacement, rotation, tipping and first molar anchorage loss were measured on superimposed digital models over 12 weeks.

The Introduction of a Novel PAOO Technique

The aim of this study is to evaluate in a prospective, randomized, controlled clinical trail the effectiveness of preorthodontic piezotomy combined with a buccal bone augmentation (in other name periodontlly accelerated osteogenic orthodontics: PAOO)in the prevention of gingival recession, and in the acceleration of orthodontic tooth movement (OTM).

Evaluation of the Biomechanical Response of Orthodontic Tooth Movement to Clear Aligner vs Fixed Orthodontic Appliance

Abstract Background: Orthodontic tooth movement (OTM) is mediated by biologic responses of the periodontal ligament (PDL) and alveolar bone to applied mechanical forces, involving release of inflammatory mediators such as interleukin-1β (IL-1β) and prostaglandin E2 (PGE2) that promote osteoclast activation and bone remodeling. Intraoral biomarkers in gingival crevicular fluid (GCF) reflect these tissue changes and can be used to monitor inflammatory and metabolic responses during treatment. Digital technologies, including intraoral scanning and 3D superimposition, allow precise quantification of tooth movement over time. Objective: This prospective, randomized comparative clinical study aims to compare the biological and mechanical responses of orthodontic tooth movement in patients treated with clear aligners versus conventional fixed appliances. Methods: Twenty adult patients (aged 18-25 years) with mild dental crowding will be randomly assigned to either a fixed appliance group (n=10) or a clear aligner group (n=10). Baseline and follow-up GCF samples will be collected to quantify IL-1β and PGE2 using enzyme-linked immunosorbent assay (ELISA). Tooth mobility will be assessed using Periotest analysis, and 3D digital models obtained from intraoral scans will be superimposed to measure the amount of tooth movement over time. Secondary outcomes include clinical measures of mobility and patient-reported pain. Expected Outcomes: It is anticipated that both treatment modalities will induce measurable increases in inflammatory biomarkers and tooth movement; however, differences in the magnitude and temporal patterns of IL-1β, PGE2, tooth mobility, and 3D-quantified displacement are expected due to the continuous forces of fixed appliances versus intermittent forces of aligners. Previous studies have shown that GCF cytokine levels rise with orthodontic force application in both aligner and fixed appliance treatments, with some variations between groups. Conclusion: This study will provide new clinical evidence comparing biological mediator profiles and mechanical outcomes between clear aligners and fixed orthodontic appliances, improving understanding of tissue responses and informing clinical decision-making in contemporary orthodontic practice

Impact of Aligner Replacement Protocols on Predictability of Planned Dental Movements: Evaluation of Double Aligner

The study will evaluate the impact of replacing aligners after 7 days with new aligners made of different materials on the predictability of planned dental movements. Three groups of participants will follow different aligner protocols, and the planned movements will be compared with the achieved ones. The study aims to provide relevant data for clinical practices with orthodontic aligners and assess participants' satisfaction with the treatment.