Clinical Research Directory

Evaluation of a Scalable Educational Intervention for Adjustment and Coping to Vision Loss

The goal of this interventional study is to learn if an educational intervention improves awareness in people experiencing visual loss. The main question it aim to answer is: * Will participants have an improved awareness of shared experiences regarding themes such as grief and isolation? Participants will be asked to answer questions, engage with an audiovisual educational intervention, and then answer additional questions.

Prospective Evaluation of the 2022 Optic Neuritis Criteria When Optic Neuritis Is Suspected

Optic neuritis is an important cause of acute or subacute visual loss. In clinical practice, optic neuritis must often be distinguished from other optic neuropathies, retinal diseases, anterior-segment or ocular media disorders, non-organic visual loss, and other mimics. The 2022 International Criteria for Optic Neuritis were developed to standardize the diagnosis of optic neuritis, but their performance in Chinese clinical settings, where aquaporin-4 immunoglobulin G-positive and myelin oligodendrocyte glycoprotein immunoglobulin G-positive optic neuritis are relatively common, remains uncertain. This multicenter prospective observational study is enrolling patients with acute or subacute visual loss in whom optic neuritis is included in the differential diagnosis. The study is designed to evaluate the diagnostic performance of the 2022 International Criteria for Optic Neuritis alone and with an antibody-stratified adjunct. The index classifications will be compared with an expert-adjudicated reference-standard diagnosis. No experimental treatment is assigned by the study. All diagnostic tests and treatments are determined by the treating clinicians according to routine clinical care. Study data are collected using a structured protocol-defined case report form.