Clinical Research Directory

Inclusion Criteria: * Age 23 or less years at time of enrollment * Diagnosis of a hematologic malignancy, including: * Acute myeloid leukemia (primary or secondary) in remission or \<10% bone marrow blasts * Acute lymphoblastic leukemia in hematologic remission * Myelodysplastic syndrome * Chronic myelogenous leukemia (chronic phase, accelerated phase, or blast crisis in second chronic phase) * Mixed lineage or biphenotypic acute leukemia * Lymphoblastic lymphoma in remission * Burkitt lymphoma/leukemia in remission * Eligible for allogeneic hematopoietic stem cell transplantation (HSCT) per institutional criteria: * Availability of an appropriate donor: * Unrelated donor with up to one antigen mismatch or defined allele mismatch * Partially matched related donor, including haploidentical donors * Adequate organ function as per institutional bone marrow transplant (BMT) standards * No active, uncontrolled infection * Patients with prior fungal infection must have received ≥2 weeks of appropriate therapy and be clinically stable * Negative pregnancy test for females of childbearing potential * Ability to provide informed consent (≥18 years) or consent provided by parent/legal guardian Exclusion Criteria: * Does not meet disease eligibility criteria * Inadequate organ function or uncontrolled infection * No suitable donor available * Prior allogeneic stem cell transplantation