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Allogeneic Stem Cell Transplant With Alpha/Beta T AND B Cell Depletion for Hematologic Malignancies
Sponsor: Children's Hospital of Philadelphia
Summary
This is a single arm pilot study for patients using α/β T cell-depleted peripheral Stem Cell Transplantation (PSCT) in with alternative donor sources with hematologic malignancies receiving alternative donor (unrelated or partially matched related) mobilized peripheral stem cells (PSCs) using the CliniMACS system for T cell depletion plus CD19+ B cell depletion to determine efficacy as determined by engraftment and graft versus host disease (GVHD), and one year leukemia free survival.
Official title: UNRELATED AND PARTIALLY MATCHED RELATED DONOR PERIPHERAL STEM CELL TRANSPLANTATION WITH Alpha/Beta T CELL AND B CELL DEPLETION FOR PATIENTS WITH HEMATOLOGIC MALIGNANCIES
Key Details
Gender
All
Age Range
Any - 23 Years
Study Type
INTERVENTIONAL
Enrollment
140
Start Date
2014-10
Completion Date
2027-10
Last Updated
2025-10-31
Healthy Volunteers
No
Conditions
Interventions
Alpha Beta T cell depletion
Locations (1)
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States