Clinical Research Directory

Inclusion Criteria: * Age≥ 65 years * Capability to sign informed consent. * No cardiac or cerebrovascular ischemia previous events one year prior to inclusion. Exclusion Criteria: * Previous treatment with HBOT for any other reason during the last 3 months prior to inclusion. * Any history of malignancy during the last year prior to inclusion. * Severe cognitive decline (MMSA\<17) * Severe chronic renal failure (GFR \<30) * Uncontrolled diabetes mellitus (HbA1C\>8, fasting glucose\>200) * Immunosuppressant from any reason * Contraindications to perform MRI: claustrophobia, allergy to gadolinium, foreign bodies, pacemaker, etc. * Active Smoking. * Pulmonary diseases such as severe emphysema, moderate-severe obstructive disease. * Medical conditions deemed by the investigator to make the patient ineligible for protocol investigations.