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Next Generation Sequencing (NGS) in Familial Acute Myeloid Leukemia and Myelodisplastic Syndromes
Sponsor: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Summary
The aim of this study is to look for predisposing mutations in patients and relatives affected by AML and MDS with familial history of myeloid or, less frequently, lymphoid malignancies. Taking advantage of a next generation sequencing (NGS) platform, screening for known and unknown mutations potentially associated with the disease will be done. The screening will be performed on affected and unaffected family members, in order to outline new pedigrees that either validate previous findings or constitute novel discoveries.
Official title: Next Generation Sequencing (NGS) Approach to Study Known and New Germline Mutations in Familial Acute Myeloid Leukemia and Myelodisplastic Syndromes
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
20
Start Date
2017-02-09
Completion Date
2025-12-31
Last Updated
2025-10-06
Healthy Volunteers
No
Conditions
Interventions
Analysis with molecular biology
Molecular screening by next generation sequencing (NGS) platform, for known and unknown mutations potentially associated with the disease
Locations (1)
Chair of Hematology and Bone marrow Transplant Unit
Brescia, Italy