Clinical Research Directory

Inclusion Criteria: * The patient is over 18 years old, * The dental crowding of the patient does not exceed 12 mm. The crowding, measured from the right mandibular canine to the left mandibular canine, doesn't require extraction or orthognathic surgery. * The patient has no active periodontal disease and no history of treated periodontal disease. * The patient has good dental hygiene. * The patient has no untreated decay. * The patient accepts the wear of metallic orthodontic materials. Exclusion Criteria: The patient : * is not able to understand the information given by the practitioner for legal, psychological or linguistic reasons. * will have predictable follow-up difficulties. * is pregnant. * has a high risk of endocarditis. * has severe or acquired immune deficiency. * has a malignant condition, an history of radiotherapy in the mandibular region. * has severe hematology, hemophilia, chronic renal failure, autoimmune disease, a condition requiring organ transplantation, poorly controlled diabetes, osteoporosis, rheumatoid arthritis or psychiatric illness. * is under antimitotic, immunosuppressive or high dose corticosteroid treatment. * smokes more than 10 cigarettes per day. * has a systemic disease that affects bone, such as osteoporosis, hyperparathyroidism, or vitamin D deficiency.