Clinical Research Directory

Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * In good general health as evidenced by medical history * For females of reproductive potential: use of highly effective contraception * Score of 1--3 on a validated transverse neck line scale3 Exclusion Criteria: * Subjects with allergies to hyaluronic acid filler. * Subjects with auto--immune conditions * Subjects with diabetes * Subjects taking anti--coagulants, diuretics, anti-histamines, or anti--inflammatory medications in the 2 weeks prior to the study or who will need to take these medications at any time during the 60 day study. * Subjects with any scheduled laser, light, or surgical procedures during the study, including dental surgery. * Subjects who had neuromodulators in the past 6 months or fillers in the previous 2 years in the neck area * Subjects who at any time had surgery or permanent fillers in the neck area * Subjects with scars, tattoos, or many skin growths in the neck area * Subjects unwilling or unable to sit still while an injector places Restylane Refyne in the neck * Subjects unwilling or unable to keep their head still during the photos * Subjects who are pregnant or nursing * Female subjects unable to take or use some form of birth control * Subjects with any neck bruising or swelling * Subjects with current skin infections, tumors, herpes outbreak or dermatitis on the neck